Axicabtagene Ciloleucel

Common brands: Yescarta, Cyclophosphamide, Frindovyx, Fludarabine, Rituxan

Top reporter: Kite Pharma, Inc.

CD19-directed Chimeric Antigen Receptor [EPC]Genetically-modified Autologous T Cells [EPC]Alkylating Drug [EPC]Corticosteroid [EPC]CD20-directed Cytolytic Antibody [EPC]
9,420
Total Reports
7,015
Serious Reports
2,499
Death Reports
30
Reported Reactions
Death Report Ratio: High (26.53%)

Patient Demographics

Male
4,454
Female
2,795

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Axicabtagene Ciloleucel.

# Reaction Reports % of Total
1 CYTOKINE RELEASE SYNDROME 4,375
27.0%
2 IMMUNE EFFECTOR CELL-ASSOCIATED NEUROTOXICITY SYNDROME 1,981
12.2%
3 NEUROTOXICITY 1,363
8.4%
4 DEATH 925
5.7%
5 PYREXIA 891
5.5%
6 DISEASE PROGRESSION 785
4.8%
7 NEUTROPENIA 471
2.9%
8 HYPOTENSION 388
2.4%
9 DIFFUSE LARGE B-CELL LYMPHOMA 363
2.2%
10 CONFUSIONAL STATE 299
1.8%
11 FEBRILE NEUTROPENIA 293
1.8%
12 ENCEPHALOPATHY 286
1.8%
13 DRUG INEFFECTIVE 269
1.7%
14 MYELODYSPLASTIC SYNDROME 261
1.6%
15 FATIGUE 258
1.6%
16 PANCYTOPENIA 256
1.6%
17 THROMBOCYTOPENIA 251
1.5%
18 APHASIA 237
1.5%
19 TREMOR 227
1.4%
20 ANAEMIA 219
1.4%
21 HYPOXIA 211
1.3%
22 HEADACHE 189
1.2%
23 CYTOPENIA 187
1.2%
24 OFF LABEL USE 182
1.1%
25 PNEUMONIA 182
1.1%
26 NEUTROPHIL COUNT DECREASED 181
1.1%
27 PLATELET COUNT DECREASED 178
1.1%
28 TACHYCARDIA 178
1.1%
29 ASTHENIA 162
1.0%
30 SOMNOLENCE 157
1.0%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.