Aflibercept

Common brands: Eylea, Eylea Hd, Lucentis, Avastin, Efudex

Top reporter: Regeneron Pharmaceuticals, Inc.

Vascular Endothelial Growth Factor Inhibitor [EPC]Nucleoside Metabolic Inhibitor [EPC]Nonsteroidal Anti-inflammatory Drug [EPC]Corticosteroid [EPC]HMG-CoA Reductase Inhibitor [EPC]

30,608

Total Reports

16,469

Serious Reports

8,871

Death Reports

Reported Reactions

Death Report Ratio: High (28.98%)

Patient Demographics

Male

5,373

Female

5,877

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Aflibercept.

#	Reaction	Reports	% of Total
1	DEATH	7,866	24.7%
2	VISUAL IMPAIRMENT	2,088	6.6%
3	OFF LABEL USE	1,596	5.0%
4	BLINDNESS	1,469	4.6%
5	ENDOPHTHALMITIS	1,395	4.4%
6	VISUAL ACUITY REDUCED	1,268	4.0%
7	EYE PAIN	1,205	3.8%
8	VISION BLURRED	1,191	3.7%
9	DRUG INEFFECTIVE	1,190	3.7%
10	PRODUCT DOSE OMISSION ISSUE	1,125	3.5%
11	BLINDNESS UNILATERAL	1,081	3.4%
12	BLINDNESS TRANSIENT	1,035	3.3%
13	EYE INFLAMMATION	996	3.1%
14	EYE HAEMORRHAGE	814	2.6%
15	VITREOUS FLOATERS	792	2.5%
16	INTRAOCULAR PRESSURE INCREASED	767	2.4%
17	RETINAL HAEMORRHAGE	586	1.8%
18	CATARACT	559	1.8%
19	DIARRHOEA	468	1.5%
20	NON-INFECTIOUS ENDOPHTHALMITIS	461	1.4%
21	UVEITIS	443	1.4%
22	VITRITIS	431	1.4%
23	HEADACHE	425	1.3%
24	OCULAR HYPERAEMIA	416	1.3%
25	HYPERTENSION	389	1.2%
26	CEREBROVASCULAR ACCIDENT	358	1.1%
27	PRODUCT USE ISSUE	355	1.1%
28	INJECTION SITE PAIN	351	1.1%
29	EYE DISORDER	349	1.1%
30	HOSPITALISATION	327	1.0%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.