Conjugated Estrogens / Medroxyprogesterone Acetate

Common brands: Prempro, Premarin, Premarin Vaginal, Provera, Depo-Provera

Top reporter: Wyeth Pharmaceuticals Llc, A Subsidiary Of Pfizer Inc.

Estrogen [EPC]Nonsteroidal Anti-inflammatory Drug [EPC]Benzodiazepine [EPC]Platelet Aggregation Inhibitor [EPC]Corticosteroid [EPC]
23,439
Total Reports
1,558
Serious Reports
647
Death Reports
30
Reported Reactions
Death Report Ratio: Moderate (2.76%)

Patient Demographics

Male
21
Female
22,869

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Conjugated Estrogens / Medroxyprogesterone Acetate.

# Reaction Reports % of Total
1 BREAST CANCER 7,888
31.6%
2 BREAST CANCER FEMALE 5,790
23.2%
3 BREAST CANCER METASTATIC 1,506
6.0%
4 DRUG INEFFECTIVE 730
2.9%
5 CEREBROVASCULAR ACCIDENT 502
2.0%
6 DEPRESSION 478
1.9%
7 HEADACHE 422
1.7%
8 ANXIETY 418
1.7%
9 NAUSEA 411
1.6%
10 DEEP VEIN THROMBOSIS 397
1.6%
11 FATIGUE 392
1.6%
12 HOT FLUSH 388
1.6%
13 PAIN 381
1.5%
14 INSOMNIA 380
1.5%
15 MYOCARDIAL INFARCTION 378
1.5%
16 OESTROGEN RECEPTOR ASSAY POSITIVE 374
1.5%
17 PULMONARY EMBOLISM 354
1.4%
18 PROGESTERONE RECEPTOR ASSAY POSITIVE 333
1.3%
19 BREAST CANCER IN SITU 331
1.3%
20 MALAISE 309
1.2%
21 OVARIAN CANCER 307
1.2%
22 HYPERTENSION 305
1.2%
23 DIZZINESS 298
1.2%
24 THROMBOSIS 295
1.2%
25 FEELING ABNORMAL 285
1.1%
26 FALL 264
1.1%
27 PAIN IN EXTREMITY 260
1.0%
28 ARTHRALGIA 256
1.0%
29 DYSPNOEA 249
1.0%
30 WEIGHT INCREASED 243
1.0%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.