INSOMNIA

Adverse reaction reported in 355,764 FDA reports across 225 drugs.

355,764

Total Reports

225

Drugs Involved

Ergocalciferol

Most Reported Drug

Drugs Associated with INSOMNIA

Drugs where "INSOMNIA" was reported as an adverse event.

#	Drug	Reports	% of Total
1	Ergocalciferol	11,562	3.2%
2	Pregabalin	9,648	2.7%
3	Levothyroxine	9,545	2.7%
4	Gabapentin	9,472	2.7%
5	Quetiapine	9,200	2.6%
6	Alprazolam	7,222	2.0%
7	Ibuprofen	7,085	2.0%
8	Clonazepam	7,067	2.0%
9	Lisinopril	6,594	1.9%
10	Lorazepam	6,340	1.8%
11	Zolpidem	6,288	1.8%
12	Varenicline	5,569	1.6%
13	Ibupfrofen	5,398	1.5%
14	Simvastatin	5,246	1.5%
15	Acetaminophen, Guaifenesin, / Phenylephrine Hydrochloride	4,863	1.4%
16	Celecoxib	4,493	1.3%
17	Escitalopram	4,439	1.2%
18	Calcium	4,376	1.2%
19	Rosuvastatin	3,930	1.1%
20	Diazepam	3,893	1.1%
21	Eszopiclone	3,891	1.1%
22	Vitamin C	3,872	1.1%
23	Aripiprazole	3,854	1.1%
24	Hydrochlorothiazide	3,830	1.1%
25	Lamotrigine	3,811	1.1%
26	Losartan	3,803	1.1%
27	Citalopram	3,624	1.0%
28	Ribavirin	3,436	1.0%
29	Oxybate	3,346	0.9%
30	Apremilast	3,322	0.9%
31	Dalfampridine	3,305	0.9%
32	Sertraline	3,280	0.9%
33	Fish Oil	3,175	0.9%
34	Magnesium	3,131	0.9%
35	Peginterferon Alfa-2a	3,078	0.9%
36	Naproxen	2,996	0.8%
37	Atenolol	2,988	0.8%
38	Mirtazapine	2,955	0.8%
39	Niraparib	2,839	0.8%
40	Olanzapine	2,815	0.8%
41	Topiramate	2,768	0.8%
42	Risperidone	2,747	0.8%
43	Baclofen	2,678	0.8%
44	Loratadine	2,589	0.7%
45	Estradiol	2,469	0.7%
46	Melatonin	2,465	0.7%
47	Montelukast	2,371	0.7%
48	Fluticasone	2,238	0.6%
49	Propranolol	2,202	0.6%
50	Escitalopram Oxalate	2,067	0.6%
51	Finasteride	2,056	0.6%
52	Venlafaxine	2,055	0.6%
53	Oxycodone Hydrochloride / Acetaminophen	2,017	0.6%
54	Ciprofolxacin	1,785	0.5%
55	Duloxetine	1,751	0.5%
56	Temazepam	1,681	0.5%
57	Escitslopram	1,635	0.5%
58	Fluoxetine	1,626	0.5%
59	Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate / Amphetamine Aspartate	1,595	0.4%
60	Lamotrigine Extended-	1,570	0.4%
61	Lamotirigine	1,569	0.4%
62	Desvenlafaxine	1,562	0.4%
63	Divalproex	1,539	0.4%
64	Ezetimibe	1,502	0.4%
65	Tramadol	1,490	0.4%
66	Lisdexamfetamine Dimesylate	1,455	0.4%
67	Topiramate Spinkle	1,448	0.4%
68	Multivitamin	1,430	0.4%
69	Carbidopa / Levodopa	1,361	0.4%
70	Enzalutamide	1,357	0.4%
71	Pimavanserin	1,353	0.4%
72	Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, / Amphetamine Sulfate	1,353	0.4%
73	Hydroxyzine	1,346	0.4%
74	Olanzapine Pamoate	1,345	0.4%
75	Estrogens, Conjugated	1,342	0.4%
76	Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	1,333	0.4%
77	Clonidine	1,311	0.4%
78	Conjugated Estrogens	1,297	0.4%
79	Anastrozole	1,282	0.4%
80	Estradiol Transdermal	1,254	0.4%
81	Atomoxetine	1,243	0.3%
82	Leuprolide	1,212	0.3%
83	Diltiazem	1,194	0.3%
84	Naltrexone	1,143	0.3%
85	Modafinil	1,141	0.3%
86	Mirabegron	1,132	0.3%
87	Aripiprazole Orally Disintegrating	1,123	0.3%
88	Nicotine	1,111	0.3%
89	Paroxetine	1,106	0.3%
90	Triamcinolone Acetonide	1,104	0.3%
91	Buprenorphine Hydrochloride, Naloxone Hydrochloride	1,076	0.3%
92	Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol / Niacinamide	1,066	0.3%
93	Vitamin E	1,064	0.3%
94	Sofosbuvir	1,062	0.3%
95	Cyanocobalamin	1,043	0.3%
96	Bupropion	1,038	0.3%
97	Pirfenidone	1,025	0.3%
98	Ascorbic Acid	1,017	0.3%
99	Lurasidone	1,012	0.3%
100	Donepezil	999	0.3%
101	Hydrocodone Bitartrate / Acetaminophen	989	0.3%
102	Armodafinil	967	0.3%
103	Biotin	927	0.3%
104	Oxide	919	0.3%
105	Vortioxetine	916	0.3%
106	Zinc Gluconate	907	0.3%
107	Lithium	903	0.3%
108	Lithium Bromatum	903	0.3%
109	Sumatriptan	888	0.2%
110	Zinc Chloride	879	0.2%
111	Zinc	876	0.2%
112	Nirmatrelvir / Ritonavir	867	0.2%
113	Fenofibrate	867	0.2%
114	Testosterone	843	0.2%
115	Clarithromycin	839	0.2%
116	Ledipasvir / Sofosbuvir	835	0.2%
117	Guaifenesin	834	0.2%
118	Ibuprofen / Diphenhydramine Citrate	833	0.2%
119	Carisoprodol	830	0.2%
120	Relugolix	816	0.2%
121	Ziprasidone	803	0.2%
122	Exemestane	787	0.2%
123	Amitriptyline	781	0.2%
124	Levocetirizine Dihydrochloride	768	0.2%
125	Oxcarbazepine	766	0.2%
126	Progesterone	764	0.2%
127	Methylphenidate	723	0.2%
128	Lithium Carbonate	723	0.2%
129	Loratadine / Pseudoephedrine Sulfate	718	0.2%
130	Candesartan Cilexetil	679	0.2%
131	Trazodone	676	0.2%
132	Suvorexant	676	0.2%
133	Isosorbide Dinitrate	646	0.2%
134	Dimenhydrinate	641	0.2%
135	Tizanidine	637	0.2%
136	Isosorbide Mononitrate	625	0.2%
137	Lovastatin	622	0.2%
138	Nicotine Polacrilex	621	0.2%
139	Paliperidone Palmitate	621	0.2%
140	Vilazodone	613	0.2%
141	Methocarbamol	606	0.2%
142	Naproxen Sodium, Pseudoephedrine Hydrochloride	591	0.2%
143	Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	591	0.2%
144	Alemtuzumab	587	0.2%
145	Ciprofloxacin Hydrochloride / Hydrocortisone	576	0.2%
146	Pramipexole	573	0.2%
147	Valbenazine	565	0.2%
148	Dutasteride	563	0.2%
149	Amantadine	561	0.2%
150	Tamsulosin	559	0.2%
151	Fosaprepitant Dimeglumine	549	0.2%
152	Telmisartan	543	0.2%
153	Ropinirole	538	0.2%
154	Fexofenadine	536	0.2%
155	Promethazine	536	0.2%
156	Linagliptin	536	0.2%
157	Felodipine	536	0.2%
158	Felodipine Extended-	535	0.2%
159	Mometasone	534	0.2%
160	Indomethacin	530	0.1%
161	Acetaminophen, Aspirin, / Caffeine	518	0.1%
162	Velpatasvir / Sofosbuvir	510	0.1%
163	Cannabidiol	499	0.1%
164	Brexpiprazole	494	0.1%
165	Solifenacin	484	0.1%
166	Pravastatin	474	0.1%
167	Medroxyprogesterone	465	0.1%
168	Clobazam	459	0.1%
169	Paliperidone	459	0.1%
170	Rivastigmine	452	0.1%
171	Rotigotine	447	0.1%
172	Acetaminophen, Aspirin (Nsaid) / Caffeine	439	0.1%
173	Meclizine	430	0.1%
174	Doxepin	420	0.1%
175	Tolterodine	405	0.1%
176	Thyroid, Porcine	401	0.1%
177	Hydrocodone	398	0.1%
178	Naltrexone Hydrochloride / Bupropion Hydrochloride	394	0.1%
179	Ezetimibe / Simvastatin	390	0.1%
180	Pitavastatin	381	0.1%
181	Conjugated Estrogens / Medroxyprogesterone Acetate	380	0.1%
182	Avapritinib	374	0.1%
183	Azelastine	370	0.1%
184	Nicotine Polacrilex Mini	368	0.1%
185	Nicotine Polarilex	368	0.1%
186	Rasagiline	368	0.1%
187	Butalbital, Acetaminophen, / Caffeine	366	0.1%
188	Zonisamide	364	0.1%
189	Liothyronine	352	0.1%
190	Omega-3-Acid Ethyl Esters	338	0.1%
191	Cariprazine	333	0.1%
192	Rizatriptan Benzoate	332	0.1%
193	Raloxifene	329	0.1%
194	Buspirone	326	0.1%
195	Elexacaftor, Tezacaftor, / Ivacaftor	321	0.1%
196	Psyllium Husk	317	0.1%
197	And Oxybates	306	0.1%
198	Asenapine	300	0.1%
199	Niacin	295	0.1%
200	Cimetidine	293	0.1%
201	Brinzolamide	281	0.1%
202	Levodopa	273	0.1%
203	Lidocaine Patch 5%	270	0.1%
204	Guanfacine	270	0.1%
205	Lisinopril / Hydrochlorothiazide	265	0.1%
206	Losartan Potassium / Hydrochlorothiazide	261	0.1%
207	Hyoscyamine	260	0.1%
208	Memantine	254	0.1%
209	Desloratadine	244	0.1%
210	Lubiprostone	239	0.1%
211	Vigabatrin	234	0.1%
212	Amlodipine Besylate / Benazepril Hydrochloride	223	0.1%
213	Clobetasol	219	0.1%
214	Clobetasol Propionate Ointment Usp, 0.05%	219	0.1%
215	Brivaracetam	217	0.1%
216	Oxybutynin Chloride	204	0.1%
217	Salmeterol	204	0.1%
218	Glecaprevir / Pibrentasvir	201	0.1%
219	Dronabinol	195	0.1%
220	Cenobamate	193	0.1%
221	Selinexor	192	0.1%
222	Icosapent Ethyl	190	0.1%
223	Apalutamide	181	0.1%
224	Dofetilide	171	0.0%
225	Amphetamine	126	0.0%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. The presence of a drug in this list does not mean the drug caused insomnia. Always consult your healthcare provider.