Pemetrexed

Common brands: Pemfexy, Axtle, Carboplatin, Kyxata, Keytruda

Top reporter: Acacia Pharma, Ltd.

Folate Analog Metabolic Inhibitor [EPC]Platinum-based Drug [EPC]Programmed Death Receptor-1 Blocking Antibody [EPC]Corticosteroid [EPC]Vitamin B12 [EPC]
20,371
Total Reports
13,801
Serious Reports
3,627
Death Reports
30
Reported Reactions
Death Report Ratio: High (17.80%)

Patient Demographics

Male
10,326
Female
7,689

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Pemetrexed.

# Reaction Reports % of Total
1 MALIGNANT NEOPLASM PROGRESSION 1,641
7.5%
2 ANAEMIA 1,221
5.6%
3 DISEASE PROGRESSION 1,090
5.0%
4 OFF LABEL USE 1,048
4.8%
5 NAUSEA 993
4.5%
6 NEUTROPENIA 981
4.5%
7 DIARRHOEA 957
4.4%
8 DRUG INEFFECTIVE 927
4.2%
9 THROMBOCYTOPENIA 919
4.2%
10 PANCYTOPENIA 907
4.1%
11 ACUTE KIDNEY INJURY 783
3.6%
12 VOMITING 770
3.5%
13 DEATH 753
3.4%
14 PNEUMONIA 746
3.4%
15 FEBRILE NEUTROPENIA 728
3.3%
16 FATIGUE 722
3.3%
17 DYSPNOEA 650
3.0%
18 PYREXIA 628
2.9%
19 ASTHENIA 606
2.8%
20 DECREASED APPETITE 587
2.7%
21 RASH 561
2.6%
22 GENERAL PHYSICAL HEALTH DETERIORATION 545
2.5%
23 PNEUMONITIS 497
2.3%
24 PULMONARY EMBOLISM 436
2.0%
25 INTERSTITIAL LUNG DISEASE 427
1.9%
26 MYELOSUPPRESSION 383
1.7%
27 LEUKOPENIA 378
1.7%
28 THERAPY PARTIAL RESPONDER 369
1.7%
29 PLEURAL EFFUSION 341
1.6%
30 RESPIRATORY FAILURE 339
1.5%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.