FDA Adverse Event Analysis

Explore rankings and insights derived from FDA adverse event reporting data (FAERS) across 500 drugs.

500
Drugs Tracked
123
Adverse Reactions
161,178,634
Total Reports

Most Reported Drugs

Drugs with the highest number of FDA adverse event reports. Higher counts often reflect wider usage.

# Drug Total Reports Serious Deaths
1 HUMIRA 695,826 196,301 28,959
2 ENBREL 591,577 67,663 16,506
3 ECOTRIN 499,686 169,560 45,970
4 ASPIRIN 325 499,522 168,629 45,850
5 ASPIRIN 81 499,522 168,629 45,850
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Highest Death Report Ratio

Drugs where the highest percentage of reports involve a death outcome (min. 1,000 reports). This does NOT indicate the drug caused any deaths.

# Drug Death Ratio Death Reports Total Reports
1 GENEXA INFANTS PAIN AND FEVER 19.6% 46,896 239,317
2 MEJORALITO 19.6% 46,896 239,317
3 RUGBY REGULAR STRENGTH ACETAMINOPHEN 19.6% 46,896 239,317
4 REGULAR STRENGTH ACETAMINOPHEN 19.6% 46,896 239,318
5 ACETAMINOPHEN EXTENDED-RELEASE 19.6% 46,896 239,321
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Drug Classes by Total Reports

Pharmacological drug classes ranked by total adverse event reports across all drugs in the class.

# Drug Class Total Reports Drugs Avg Death Ratio
1 Nonsteroidal Anti-inflammatory Drug [EPC] 158,681,233 494 13.77%
2 Corticosteroid [EPC] 158,128,191 488 13.77%
3 Proton Pump Inhibitor [EPC] 83,687,107 331 17.71%
4 Platelet Aggregation Inhibitor [EPC] 78,156,796 174 9.25%
5 Loop Diuretic [EPC] 76,214,814 168 9.28%
6 Vitamin C [EPC] 73,746,236 300 18.63%
7 Benzodiazepine [EPC] 72,257,532 296 19.07%
8 HMG-CoA Reductase Inhibitor [EPC] 67,016,251 140 9.18%
9 Folate Analog Metabolic Inhibitor [EPC] 8,371,856 22 8.28%
10 Tumor Necrosis Factor Blocker [EPC] 6,198,983 13 7.97%
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Most Common Adverse Reactions

The most frequently reported adverse reactions across all drugs in the database.

# Reaction Total Reports Drugs Reporting
1 FATIGUE 11,561,068 499
2 OFF LABEL USE 10,077,442 500
3 DRUG INEFFECTIVE 9,988,325 500
4 NAUSEA 9,822,201 499
5 PAIN 8,854,826 500
6 DYSPNOEA 8,799,278 499
7 DIARRHOEA 8,555,594 499
8 HEADACHE 8,339,258 499
9 ARTHRALGIA 7,020,968 490
10 VOMITING 6,887,655 497
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All Rankings

Drugs with the Most FDA Adverse Event Reports → Drugs with the Most Serious Adverse Event Reports → Drugs with the Most Death Reports → Drugs with the Highest Death Report Ratio → Drugs with the Most Reported Side Effects → Most Commonly Reported Adverse Reactions → Drug Classes by Total Adverse Event Reports →

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. These rankings reflect reporting volume, not drug safety. Always consult your doctor or pharmacist before making medication decisions.