Bupivacaine

Common brands: Exparel, Bupivacaine Spinal, Fentanyl, Fentanyl System, Pain Relief

Top reporter: Pacira Pharmaceuticals, Inc.

Amide Local Anesthetic [EPC]Opioid Agonist [EPC]Antiarrhythmic [EPC]Non-Standardized Chemical Allergen [EPC]Nonsteroidal Anti-inflammatory Drug [EPC]
9,180
Total Reports
3,345
Serious Reports
565
Death Reports
30
Reported Reactions
Death Report Ratio: High (6.15%)

Patient Demographics

Male
2,497
Female
4,520

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Bupivacaine.

# Reaction Reports % of Total
1 OFF LABEL USE 882
10.0%
2 PAIN 767
8.7%
3 DRUG INEFFECTIVE 705
8.0%
4 HYPOTENSION 532
6.0%
5 NAUSEA 405
4.6%
6 HYPOAESTHESIA 374
4.2%
7 MATERNAL EXPOSURE DURING PREGNANCY 370
4.2%
8 EXPOSURE DURING PREGNANCY 334
3.8%
9 DRUG WITHDRAWAL SYNDROME 281
3.2%
10 VOMITING 274
3.1%
11 LABELLED DRUG-DRUG INTERACTION MEDICATION ERROR 248
2.8%
12 MATERNAL EXPOSURE DURING DELIVERY 240
2.7%
13 OVERDOSE 234
2.6%
14 FOETAL EXPOSURE DURING PREGNANCY 225
2.5%
15 NO ADVERSE EVENT 217
2.5%
16 DYSPNOEA 211
2.4%
17 MUSCULAR WEAKNESS 211
2.4%
18 SOMNOLENCE 211
2.4%
19 DIZZINESS 207
2.3%
20 BRADYCARDIA 205
2.3%
21 PREMATURE BABY 200
2.3%
22 CARDIAC ARREST 188
2.1%
23 ASTHENIA 186
2.1%
24 HEADACHE 181
2.0%
25 BACK PAIN 172
1.9%
26 LOSS OF CONSCIOUSNESS 169
1.9%
27 PARAESTHESIA 166
1.9%
28 CONDITION AGGRAVATED 155
1.8%
29 DRUG INTERACTION 153
1.7%
30 HYPERHIDROSIS 152
1.7%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.