CONDITION AGGRAVATED

Adverse reaction reported in 772,824 FDA reports across 339 drugs.

772,824

Total Reports

339

Drugs Involved

Prednisone

Most Reported Drug

Drugs Associated with CONDITION AGGRAVATED

Drugs where "CONDITION AGGRAVATED" was reported as an adverse event.

#	Drug	Reports	% of Total
1	Prednisone	28,167	3.6%
2	Etanercept	20,646	2.7%
3	Methotrexate	19,836	2.6%
4	Dupilumab	19,621	2.5%
5	Tofacitinib	19,599	2.5%
6	Infliximab	19,127	2.5%
7	Adalimumab	16,537	2.1%
8	Acetaminophen	13,368	1.7%
9	Folic Acid	11,292	1.5%
10	Ergocalciferol	11,230	1.5%
11	Infliximab-Dyyb	10,590	1.4%
12	Leflunomide	10,504	1.4%
13	Pain Reliever	9,752	1.3%
14	Rituximab	9,504	1.2%
15	Tocilizumab	9,503	1.2%
16	Sulfasalazine	9,477	1.2%
17	Abatacept	9,026	1.2%
18	Pantoprazole	8,956	1.2%
19	Pregabalin	8,600	1.1%
20	Secukinumab	8,349	1.1%
21	Gabapentin	8,215	1.1%
22	Ibuprofen	7,444	1.0%
23	Hydroxychloroquine	7,093	0.9%
24	Hydrocortisone	6,830	0.9%
25	Certolizumab Pegol	6,649	0.9%
26	Azathioprine	6,458	0.8%
27	Celecoxib	6,305	0.8%
28	Golimumab	6,262	0.8%
29	Ibupfrofen	5,949	0.8%
30	Quetiapine	5,947	0.8%
31	Diclofenac	5,929	0.8%
32	Methylprednisolone	5,900	0.8%
33	Prednisolone	5,875	0.8%
34	Lorazepam	5,521	0.7%
35	Hydrocortisone 1%	5,328	0.7%
36	Anti Itch	5,322	0.7%
37	Anti-Itch	5,322	0.7%
38	Anti-Pruritic	5,322	0.7%
39	Antipruritic (Anti-Itch)	5,322	0.7%
40	Cool Relief With Aloe	5,322	0.7%
41	Drs Hydrocortisone	5,322	0.7%
42	Hydrocortisone Continuous Spray	5,322	0.7%
43	Hydrocortisone Spray	5,322	0.7%
44	Adapalene	5,262	0.7%
45	Ustekinumab	5,135	0.7%
46	Desoximetasone	4,907	0.6%
47	Calcium	4,828	0.6%
48	Ramipril	4,694	0.6%
49	Adalimumab-Adaz	4,683	0.6%
50	Mesalamine	4,526	0.6%
51	Adalimumab-Aaty	4,353	0.6%
52	Mycophenolate	4,341	0.6%
53	Adalimumab-Fkjp	4,300	0.6%
54	Lansoprazole	4,285	0.6%
55	Clonazepam	4,161	0.5%
56	Escitalopram	3,969	0.5%
57	Apremilast	3,774	0.5%
58	Naproxen	3,714	0.5%
59	Lamotrigine	3,649	0.5%
60	Sarilumab	3,646	0.5%
61	Albuterol	3,512	0.5%
62	Spironolactone	3,510	0.5%
63	Dalfampridine	3,482	0.5%
64	Vitamin C	3,348	0.4%
65	Carbonate	3,196	0.4%
66	Aripiprazole	3,176	0.4%
67	Cyclosporine	3,150	0.4%
68	Levetiracetam	3,118	0.4%
69	Risperidone	3,088	0.4%
70	Tacrolimus	3,058	0.4%
71	Sertraline	3,014	0.4%
72	Bisoprolol	2,961	0.4%
73	Olanzapine	2,907	0.4%
74	Topiramate	2,896	0.4%
75	Doxycycline	2,894	0.4%
76	Doxycycline Hyclate	2,866	0.4%
77	Oxybate	2,802	0.4%
78	Budesonide	2,769	0.4%
79	Mepolizumab	2,670	0.3%
80	Diphenhydramine	2,626	0.3%
81	Escitalopram Oxalate	2,615	0.3%
82	Macitentan	2,614	0.3%
83	Antacid	2,613	0.3%
84	Tacrolimus Extended-	2,598	0.3%
85	Warfarin	2,581	0.3%
86	Ciprofloxacin	2,572	0.3%
87	Magnesium	2,453	0.3%
88	Fish Oil	2,367	0.3%
89	Baclofen	2,367	0.3%
90	Fluticasone	2,286	0.3%
91	Pimavanserin	2,244	0.3%
92	Levetiracetam In Chloride	2,222	0.3%
93	Montelukast	2,205	0.3%
94	Mirtazapine	2,190	0.3%
95	Lamotrigine Extended-	2,186	0.3%
96	Lamotirigine	2,186	0.3%
97	Iron	2,181	0.3%
98	Ciprofolxacin	2,145	0.3%
99	Meloxicam	2,124	0.3%
100	Metronidazole	2,081	0.3%
101	Topiramate Spinkle	2,053	0.3%
102	Teriflunomide	2,014	0.3%
103	Escitslopram	2,009	0.3%
104	Carbamazepine	2,007	0.3%
105	Candesartan	1,983	0.3%
106	Sildenafil	1,975	0.3%
107	Docosanol	1,957	0.3%
108	Risedronate	1,948	0.3%
109	Loratadine	1,916	0.2%
110	Venlafaxine	1,912	0.2%
111	Glycerin, Lidocaine	1,895	0.2%
112	Propranolol	1,882	0.2%
113	Bosentan	1,869	0.2%
114	Vancomycin	1,868	0.2%
115	Duloxetine	1,747	0.2%
116	Azithromycin	1,704	0.2%
117	Fluticasone Propionate / Salmeterol Xinafoate	1,684	0.2%
118	Fluoxetine	1,680	0.2%
119	Triamcinolone Acetonide	1,673	0.2%
120	Salicylic Acid	1,657	0.2%
121	Anakinra	1,652	0.2%
122	Aripiprazole Orally Disintegrating	1,629	0.2%
123	Levofloxacin	1,568	0.2%
124	Levofloxacin In 5% Dextrose	1,568	0.2%
125	Fluconazole	1,561	0.2%
126	Triamcinolone Acetonide Ointment Usp, 0.05%	1,530	0.2%
127	Melatonin	1,519	0.2%
128	Oxygen	1,508	0.2%
129	0xygen	1,507	0.2%
130	Esomeprazole	1,480	0.2%
131	Amoxicillin	1,446	0.2%
132	Eculizumab	1,401	0.2%
133	Cyanocobalamin	1,342	0.2%
134	Ipratropium Bromide	1,339	0.2%
135	Mirabegron	1,331	0.2%
136	Ceftriaxone	1,318	0.2%
137	Carbidopa / Levodopa	1,274	0.2%
138	Bupropion	1,243	0.2%
139	Meropenem	1,192	0.2%
140	Oxide	1,184	0.2%
141	Selexipag	1,183	0.2%
142	Diltiazem	1,164	0.2%
143	Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate / Amphetamine Aspartate	1,151	0.1%
144	Gluconate	1,143	0.1%
145	Modafinil	1,129	0.1%
146	Hydroxyzine	1,117	0.1%
147	Voriconazole	1,113	0.1%
148	Dexlansoprazole	1,082	0.1%
149	Fluticasone Furoate / Vilanterol Trifenatate	1,064	0.1%
150	Ciclesonide	1,064	0.1%
151	Piperacillin Sodium,Tazobactam Sodium	1,056	0.1%
152	Fluticasone Furoate, Umeclidinium Bromide / Vilanterol Trifenatate	1,048	0.1%
153	Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	1,042	0.1%
154	Valproic Acid	1,034	0.1%
155	Caffeine	1,030	0.1%
156	Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, / Amphetamine Sulfate	1,029	0.1%
157	Doxyclycline Hyclate	1,027	0.1%
158	Divalproex	1,015	0.1%
159	Lisdexamfetamine Dimesylate	1,013	0.1%
160	Torsemide	996	0.1%
161	Paliperidone Palmitate	979	0.1%
162	Belimumab	969	0.1%
163	Tobramycin	956	0.1%
164	Lactulose	941	0.1%
165	Desvenlafaxine	932	0.1%
166	Ascorbic Acid	931	0.1%
167	Latanoprost	923	0.1%
168	Donepezil	916	0.1%
169	Bimekizumab	911	0.1%
170	Paroxetine	886	0.1%
171	Amphotericin B	865	0.1%
172	Canakinumab	853	0.1%
173	Biotin	852	0.1%
174	Estradiol Transdermal	851	0.1%
175	Colchicine	851	0.1%
176	Oxcarbazepine	847	0.1%
177	Clindamycin	843	0.1%
178	Botulinum Toxin Type A	821	0.1%
179	Clobazam	808	0.1%
180	Pramipexole	808	0.1%
181	Lithium	807	0.1%
182	Lithium Bromatum	807	0.1%
183	Haloperidol Lactate	807	0.1%
184	Epoprostenol	797	0.1%
185	Valacyclovir	795	0.1%
186	Haloperidol	793	0.1%
187	Norepinephrine ( )	781	0.1%
188	Zinc Gluconate	776	0.1%
189	Linezolid	763	0.1%
190	Moxifloxacin	762	0.1%
191	Clarithromycin	756	0.1%
192	Insulin Glargine-Yfgn	740	0.1%
193	Zinc Chloride	734	0.1%
194	Zinc	731	0.1%
195	Minocycline	730	0.1%
196	Nystatin	721	0.1%
197	Alemtuzumab	718	0.1%
198	Minoxidil	710	0.1%
199	Lacosamide	709	0.1%
200	Lamivudine	706	0.1%
201	Dimenhydrinate	706	0.1%
202	Crisaborole	704	0.1%
203	Minoxidil Foam 5% (Womens)	696	0.1%
204	Armodafinil	694	0.1%
205	Atomoxetine	691	0.1%
206	Sumatriptan	681	0.1%
207	Candesartan Cilexetil	681	0.1%
208	Loperamide Hydrochloride / Dimethicone	676	0.1%
209	Levodopa	675	0.1%
210	Mycophenolic Acid	670	0.1%
211	Rabeprazole	655	0.1%
212	Rifaximin	633	0.1%
213	Midazolam	611	0.1%
214	Dornase Alfa	610	0.1%
215	Amantadine	608	0.1%
216	Guselkumab	607	0.1%
217	Cannabidiol	607	0.1%
218	Propofol	601	0.1%
219	Lurasidone	601	0.1%
220	Rivastigmine	601	0.1%
221	Bisacodyl	596	0.1%
222	Amikacin	591	0.1%
223	Rifampin	589	0.1%
224	Biscodyl	584	0.1%
225	Droxidopa	583	0.1%
226	Bisacodyl Suppositories	582	0.1%
227	Norepinephrine	577	0.1%
228	Doxazosin	576	0.1%
229	Tizanidine	574	0.1%
230	Mometasone	562	0.1%
231	Phenytoin	560	0.1%
232	Oxybutynin	559	0.1%
233	Amoxicillin / Clavulanate Potassium	559	0.1%
234	Erythromycin	558	0.1%
235	Fluticasone Furoate	548	0.1%
236	Dutasteride	538	0.1%
237	Methylphenidate	534	0.1%
238	Miconazole Nitrate	526	0.1%
239	Bicarbonate	521	0.1%
240	Thiamine	521	0.1%
241	Valproate	517	0.1%
242	Tamsulosin	517	0.1%
243	Paliperidone	513	0.1%
244	Memantine	511	0.1%
245	Umeclidinium Bromide / Vilanterol Trifenatate	510	0.1%
246	Mycophenilic Acid	501	0.1%
247	Isoniazid	495	0.1%
248	Ropinirole	493	0.1%
249	Brimonidine	482	0.1%
250	Alirocumab	479	0.1%
251	Ketoconazole	477	0.1%
252	Fexofenadine	469	0.1%
253	Insulin Degludec	468	0.1%
254	Zonisamide	454	0.1%
255	Levocetirizine Dihydrochloride	453	0.1%
256	Mercaptopurine	449	0.1%
257	Cefuroxime	440	0.1%
258	Clotrimazole	439	0.1%
259	Dextrose	438	0.1%
260	Polyethylene Glycol 400	436	0.1%
261	Posaconazole	432	0.1%
262	Instalax Polyethylene Glycol 3350	431	0.1%
263	Polyethylene Glycol (3350)	431	0.1%
264	Cefepime	429	0.1%
265	Benralizumab	427	0.1%
266	Theophylline	427	0.1%
267	Trimethoprim	421	0.1%
268	Drs Clotrimazole	420	0.1%
269	Family Wellness Clotrimazole	420	0.1%
270	Phenobarbital	416	0.1%
271	Gentamicin	416	0.1%
272	Ursodiol	413	0.1%
273	Mupirocin	399	0.1%
274	Vortioxetine	397	0.1%
275	Ketoconazole Foam	397	0.1%
276	Tolterodine	395	0.1%
277	Itraconazole	393	0.1%
278	Extended Phenytoin	390	0.1%
279	Pravastatin	388	0.1%
280	Heparin	387	0.1%
281	Dalteparin	382	0.0%
282	Amiodarone	381	0.0%
283	Febuxostat	380	0.0%
284	Remdesivir	379	0.0%
285	Azelastine	377	0.0%
286	Phytonadione	377	0.0%
287	Asenapine	374	0.0%
288	Ursosiol	371	0.0%
289	Leucovorin	371	0.0%
290	Metolazone	367	0.0%
291	Oseltamivir	361	0.0%
292	Eplerenone	360	0.0%
293	Cholestyramine	352	0.0%
294	Brexpiprazole	351	0.0%
295	Dapsone	345	0.0%
296	Rasagiline	340	0.0%
297	Posaconazole Delayed-	336	0.0%
298	Fesoterodine	329	0.0%
299	Daspone	329	0.0%
300	Pyrazinamide	326	0.0%
301	Ganciclovir	324	0.0%
302	Clobetasol	316	0.0%
303	Tretinoin	310	0.0%
304	Clobetasol Propionate Ointment Usp, 0.05%	306	0.0%
305	Rotigotine	300	0.0%
306	Sirolimus	300	0.0%
307	Nebivolol	299	0.0%
308	Lopinavir / Ritonavir	295	0.0%
309	Vigabatrin	285	0.0%
310	Buspirone	285	0.0%
311	Acetylcysteine	283	0.0%
312	Tafamidis	274	0.0%
313	Primidone	267	0.0%
314	Lifitegrast	264	0.0%
315	Icosapent Ethyl	263	0.0%
316	Agalsidase Beta	256	0.0%
317	Captopril	255	0.0%
318	Umeclidinium	254	0.0%
319	Atovaquone	252	0.0%
320	Thyroid, Porcine	250	0.0%
321	Ampicillin	245	0.0%
322	And Oxybates	236	0.0%
323	Sulfur	234	0.0%
324	Salmeterol	227	0.0%
325	Terbinafine	224	0.0%
326	Dofetilide	218	0.0%
327	Timolol	204	0.0%
328	Micafungin	200	0.0%
329	Rocuronium Bromide	190	0.0%
330	Guanfacine	187	0.0%
331	Dronedarone	182	0.0%
332	Atropine	173	0.0%
333	Daptomycin	170	0.0%
334	Baricitinib	162	0.0%
335	Bupivacaine	155	0.0%
336	Cabotegravir	134	0.0%
337	Cariprazine	132	0.0%
338	Nemolizumab-Ilto	118	0.0%
339	Loratadine / Pseudoephedrine Sulfate	115	0.0%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. The presence of a drug in this list does not mean the drug caused condition aggravated. Always consult your healthcare provider.