Canagliflozin

Common brands: Invokana, Metformin Hydrochloride, Metformin, Lantus, Zestril

Top reporter: Janssen Pharmaceuticals, Inc.

Insulin Analog [EPC]Nonsteroidal Anti-inflammatory Drug [EPC]GLP-1 Receptor Agonist [EPC]Sulfonylurea [EPC]HMG-CoA Reductase Inhibitor [EPC]
29,639
Total Reports
3,366
Serious Reports
682
Death Reports
30
Reported Reactions
Death Report Ratio: Moderate (2.30%)

Patient Demographics

Male
13,393
Female
12,769

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Canagliflozin.

# Reaction Reports % of Total
1 DIABETIC KETOACIDOSIS 3,423
11.0%
2 TOE AMPUTATION 2,195
7.1%
3 OSTEOMYELITIS 2,165
7.0%
4 ACUTE KIDNEY INJURY 1,994
6.4%
5 FUNGAL INFECTION 1,447
4.7%
6 WEIGHT DECREASED 1,341
4.3%
7 BLOOD GLUCOSE INCREASED 1,232
4.0%
8 GANGRENE 1,084
3.5%
9 CELLULITIS 1,035
3.3%
10 URINARY TRACT INFECTION 1,018
3.3%
11 NAUSEA 1,009
3.2%
12 OFF LABEL USE 1,008
3.2%
13 DRUG INEFFECTIVE 1,006
3.2%
14 DIZZINESS 841
2.7%
15 DIABETIC FOOT INFECTION 834
2.7%
16 LEG AMPUTATION 792
2.5%
17 DIABETIC FOOT 788
2.5%
18 DIARRHOEA 774
2.5%
19 DEHYDRATION 727
2.3%
20 RENAL FAILURE 711
2.3%
21 KETOACIDOSIS 642
2.1%
22 VOMITING 627
2.0%
23 FATIGUE 604
1.9%
24 FOOT AMPUTATION 582
1.9%
25 SEPSIS 573
1.8%
26 SKIN ULCER 570
1.8%
27 RASH 522
1.7%
28 DRUG DOSE OMISSION 514
1.7%
29 GLYCOSYLATED HAEMOGLOBIN INCREASED 514
1.7%
30 MALAISE 498
1.6%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.