Irinotecan

Common brands: Camptosar, Onivyde, Efudex, Tolak, Fluorouracil

Top reporter: Pharmacia & Upjohn Company Llc

Nucleoside Metabolic Inhibitor [EPC]Vascular Endothelial Growth Factor Inhibitor [EPC]Platinum-based Drug [EPC]Epidermal Growth Factor Receptor Antagonist [EPC]Corticosteroid [EPC]
12,343
Total Reports
6,637
Serious Reports
2,545
Death Reports
30
Reported Reactions
Death Report Ratio: High (20.62%)

Patient Demographics

Male
6,304
Female
4,579

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Irinotecan.

# Reaction Reports % of Total
1 DIARRHOEA 1,653
10.8%
2 OFF LABEL USE 1,065
6.9%
3 NAUSEA 914
6.0%
4 DEATH 873
5.7%
5 VOMITING 829
5.4%
6 DISEASE PROGRESSION 675
4.4%
7 MYELOSUPPRESSION 650
4.2%
8 NEUTROPENIA 611
4.0%
9 FEBRILE NEUTROPENIA 591
3.8%
10 FATIGUE 550
3.6%
11 MALIGNANT NEOPLASM PROGRESSION 528
3.4%
12 PYREXIA 522
3.4%
13 ASTHENIA 487
3.2%
14 ABDOMINAL PAIN 452
2.9%
15 NEUROPATHY PERIPHERAL 435
2.8%
16 DECREASED APPETITE 387
2.5%
17 NEOPLASM PROGRESSION 378
2.5%
18 NEUTROPHIL COUNT DECREASED 369
2.4%
19 WHITE BLOOD CELL COUNT DECREASED 362
2.4%
20 DEHYDRATION 358
2.3%
21 ANAEMIA 357
2.3%
22 THROMBOCYTOPENIA 291
1.9%
23 DYSPNOEA 289
1.9%
24 DRUG INEFFECTIVE 276
1.8%
25 MALAISE 257
1.7%
26 STOMATITIS 254
1.7%
27 SEPSIS 247
1.6%
28 PRODUCT USE IN UNAPPROVED INDICATION 242
1.6%
29 RASH 233
1.5%
30 PULMONARY EMBOLISM 226
1.5%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.