Sacubitril / Valsartan

Common brands: Entresto, Lasix, Coreg, Aldactone, Furosemide

Top reporter: Novartis Pharmaceuticals Corporation

Angiotensin 2 Receptor Blocker [EPC]Loop Diuretic [EPC]Aldosterone Antagonist [EPC]beta-Adrenergic Blocker [EPC]alpha-Adrenergic Blocker [EPC]
114,605
Total Reports
60,584
Serious Reports
14,085
Death Reports
30
Reported Reactions
Death Report Ratio: High (12.29%)

Patient Demographics

Male
67,974
Female
38,086

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Sacubitril / Valsartan.

# Reaction Reports % of Total
1 HYPOTENSION 11,502
9.0%
2 DEATH 9,125
7.1%
3 DYSPNOEA 8,943
7.0%
4 DIZZINESS 8,665
6.8%
5 FATIGUE 8,657
6.7%
6 COUGH 7,844
6.1%
7 WRONG TECHNIQUE IN PRODUCT USAGE PROCESS 7,305
5.7%
8 WEIGHT DECREASED 5,191
4.0%
9 CARDIAC FAILURE 4,476
3.5%
10 MALAISE 4,443
3.5%
11 ASTHENIA 3,784
2.9%
12 WEIGHT INCREASED 3,503
2.7%
13 BLOOD PRESSURE DECREASED 3,155
2.5%
14 PRODUCT DOSE OMISSION ISSUE 2,831
2.2%
15 MYOCARDIAL INFARCTION 2,770
2.2%
16 FALL 2,714
2.1%
17 INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION 2,677
2.1%
18 FEELING ABNORMAL 2,666
2.1%
19 DRUG INEFFECTIVE 2,613
2.0%
20 CARDIAC DISORDER 2,562
2.0%
21 HYPERTENSION 2,483
1.9%
22 EJECTION FRACTION DECREASED 2,478
1.9%
23 DIARRHOEA 2,465
1.9%
24 HYPOACUSIS 2,357
1.8%
25 MEMORY IMPAIRMENT 2,316
1.8%
26 PERIPHERAL SWELLING 2,263
1.8%
27 FLUID RETENTION 2,259
1.8%
28 ATRIAL FIBRILLATION 2,134
1.7%
29 COVID-19 2,104
1.6%
30 PRODUCT USE IN UNAPPROVED INDICATION 1,988
1.5%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.