Tocilizumab

Common brands: Actemra, Methotrexate, Rasuvo, Otrexup, Trexall

Top reporter: Genentech, Inc.

Interleukin-6 Receptor Antagonist [EPC]Folate Analog Metabolic Inhibitor [EPC]Corticosteroid [EPC]Tumor Necrosis Factor Blocker [EPC]Selective T Cell Costimulation Modulator [EPC]
111,773
Total Reports
46,569
Serious Reports
11,929
Death Reports
30
Reported Reactions
Death Report Ratio: High (10.67%)

Patient Demographics

Male
21,282
Female
76,537

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Tocilizumab.

# Reaction Reports % of Total
1 DRUG INEFFECTIVE 35,192
9.5%
2 RHEUMATOID ARTHRITIS 22,487
6.1%
3 OFF LABEL USE 20,081
5.4%
4 PAIN 20,015
5.4%
5 ARTHRALGIA 17,088
4.6%
6 JOINT SWELLING 16,142
4.4%
7 FATIGUE 15,172
4.1%
8 RASH 13,575
3.7%
9 DRUG INTOLERANCE 12,980
3.5%
10 CONTRAINDICATED PRODUCT ADMINISTERED 12,016
3.2%
11 ARTHROPATHY 10,766
2.9%
12 ALOPECIA 10,620
2.9%
13 ABDOMINAL DISCOMFORT 10,455
2.8%
14 SYNOVITIS 10,409
2.8%
15 SWELLING 10,349
2.8%
16 HYPERSENSITIVITY 10,070
2.7%
17 TREATMENT FAILURE 9,961
2.7%
18 SYSTEMIC LUPUS ERYTHEMATOSUS 9,555
2.6%
19 HEADACHE 9,514
2.6%
20 CONDITION AGGRAVATED 9,503
2.6%
21 INFUSION RELATED REACTION 9,292
2.5%
22 PEMPHIGUS 9,045
2.4%
23 PERIPHERAL SWELLING 8,764
2.4%
24 DRUG HYPERSENSITIVITY 8,758
2.4%
25 HEPATIC ENZYME INCREASED 8,548
2.3%
26 GLOSSODYNIA 8,375
2.3%
27 NAUSEA 8,218
2.2%
28 INFECTION 8,172
2.2%
29 THERAPEUTIC PRODUCT EFFECT DECREASED 7,926
2.1%
30 HAND DEFORMITY 7,843
2.1%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.