Valproic Acid

Common brands: Valproic, Keppra Xr, Keppra, Levetiracetam, Levetiracetam Er

Top reporter: Actavis Pharma, Inc.

Anti-epileptic Agent [EPC]Mood Stabilizer [EPC]Benzodiazepine [EPC]Atypical Antipsychotic [EPC]Nonsteroidal Anti-inflammatory Drug [EPC]
30,890
Total Reports
14,050
Serious Reports
4,593
Death Reports
30
Reported Reactions
Death Report Ratio: High (14.87%)

Patient Demographics

Male
14,376
Female
12,334

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Valproic Acid.

# Reaction Reports % of Total
1 DRUG INEFFECTIVE 3,700
11.4%
2 DRUG INTERACTION 3,491
10.8%
3 OFF LABEL USE 2,102
6.5%
4 TOXICITY TO VARIOUS AGENTS 1,968
6.1%
5 SEIZURE 1,888
5.8%
6 COMPLETED SUICIDE 1,296
4.0%
7 SOMNOLENCE 1,263
3.9%
8 DEPRESSION 1,220
3.8%
9 CONDITION AGGRAVATED 1,034
3.2%
10 OVERDOSE 946
2.9%
11 FOETAL EXPOSURE DURING PREGNANCY 903
2.8%
12 PYREXIA 878
2.7%
13 PRODUCT USE IN UNAPPROVED INDICATION 839
2.6%
14 STATUS EPILEPTICUS 748
2.3%
15 FATIGUE 706
2.2%
16 HYPOTENSION 698
2.2%
17 VOMITING 693
2.1%
18 PNEUMONIA 672
2.1%
19 TREMOR 671
2.1%
20 AGGRESSION 666
2.1%
21 EPILEPSY 655
2.0%
22 AGITATION 621
1.9%
23 THROMBOCYTOPENIA 621
1.9%
24 HYPERAMMONAEMIA 619
1.9%
25 DEATH 604
1.9%
26 NAUSEA 593
1.8%
27 WEIGHT INCREASED 587
1.8%
28 CONFUSIONAL STATE 582
1.8%
29 ANXIETY 576
1.8%
30 FALL 561
1.7%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.