Anakinra

Common brands: Kineret, Methotrexate, Rasuvo, Otrexup, Trexall

Top reporter: Swedish Orphan Biovitrum Ab (Publ)

Interleukin-1 Receptor Antagonist [EPC]Corticosteroid [EPC]Tumor Necrosis Factor Blocker [EPC]Folate Analog Metabolic Inhibitor [EPC]Interleukin-6 Receptor Antagonist [EPC]
16,150
Total Reports
4,556
Serious Reports
1,476
Death Reports
30
Reported Reactions
Death Report Ratio: High (9.14%)

Patient Demographics

Male
5,089
Female
9,750

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Anakinra.

# Reaction Reports % of Total
1 OFF LABEL USE 5,068
14.4%
2 DRUG INEFFECTIVE 4,184
11.9%
3 CONDITION AGGRAVATED 1,652
4.7%
4 PAIN 1,569
4.5%
5 RHEUMATOID ARTHRITIS 1,542
4.4%
6 JOINT SWELLING 1,187
3.4%
7 ARTHRALGIA 1,183
3.4%
8 DRUG INTOLERANCE 1,164
3.3%
9 PYREXIA 1,138
3.2%
10 INJECTION SITE PAIN 1,005
2.9%
11 RASH 966
2.8%
12 NAUSEA 945
2.7%
13 PRODUCT DOSE OMISSION ISSUE 896
2.6%
14 INFECTION 893
2.5%
15 DRUG HYPERSENSITIVITY 866
2.5%
16 VOMITING 865
2.5%
17 DIARRHOEA 862
2.5%
18 CONTRAINDICATED PRODUCT ADMINISTERED 841
2.4%
19 SYNOVITIS 800
2.3%
20 FATIGUE 757
2.2%
21 ARTHROPATHY 725
2.1%
22 INJECTION SITE ERYTHEMA 711
2.0%
23 ARTHRITIS 690
2.0%
24 TREATMENT FAILURE 681
1.9%
25 MALAISE 678
1.9%
26 THERAPEUTIC PRODUCT EFFECT DECREASED 673
1.9%
27 MOBILITY DECREASED 664
1.9%
28 C-REACTIVE PROTEIN INCREASED 640
1.8%
29 RED BLOOD CELL SEDIMENTATION RATE INCREASED 634
1.8%
30 SEPTIC SHOCK 603
1.7%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.