Caffeine

Common brands: Diurex Ultra, Diurex Ultimate, Vivarin, Stay Awake, Stay Awake Maximum Strength

Top reporter: Kobayashi Healthcare International, Inc.

Central Nervous System Stimulant [EPC]Methylxanthine [EPC]Nonsteroidal Anti-inflammatory Drug [EPC]Benzodiazepine [EPC]Corticosteroid [EPC]
7,641
Total Reports
5,166
Serious Reports
3,078
Death Reports
30
Reported Reactions
Death Report Ratio: High (40.28%)

Patient Demographics

Male
2,379
Female
4,414

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Caffeine.

# Reaction Reports % of Total
1 TOXICITY TO VARIOUS AGENTS 1,359
4.5%
2 FATIGUE 1,265
4.2%
3 PAIN 1,140
3.8%
4 OFF LABEL USE 1,095
3.6%
5 ARTHRALGIA 1,068
3.5%
6 VOMITING 1,062
3.5%
7 ALOPECIA 1,061
3.5%
8 DRUG INEFFECTIVE 1,053
3.5%
9 DYSPNOEA 1,040
3.4%
10 ABDOMINAL DISCOMFORT 1,033
3.4%
11 CONDITION AGGRAVATED 1,030
3.4%
12 HEADACHE 1,004
3.3%
13 NAUSEA 1,003
3.3%
14 DIARRHOEA 993
3.3%
15 ARTHROPATHY 974
3.2%
16 HEPATIC ENZYME INCREASED 965
3.2%
17 CONFUSIONAL STATE 960
3.2%
18 INFUSION RELATED REACTION 944
3.1%
19 PEMPHIGUS 942
3.1%
20 PERICARDITIS 942
3.1%
21 RASH 941
3.1%
22 HAND DEFORMITY 937
3.1%
23 URTICARIA 935
3.1%
24 MOBILITY DECREASED 933
3.1%
25 JOINT SWELLING 923
3.1%
26 HELICOBACTER INFECTION 921
3.1%
27 ABDOMINAL PAIN UPPER 920
3.0%
28 DUODENAL ULCER PERFORATION 919
3.0%
29 STOMATITIS 917
3.0%
30 RHEUMATOID ARTHRITIS 915
3.0%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.