Mercaptopurine

Common brands: Methotrexate, Trexall, Jylamvo, Otrexup, Rasuvo

Top reporter: Florida Pharmaceutical Products, Llc

Folate Analog Metabolic Inhibitor [EPC]Corticosteroid [EPC]Nucleoside Metabolic Inhibitor [EPC]Alkylating Drug [EPC]Asparagine-specific Enzyme [EPC]
17,055
Total Reports
6,672
Serious Reports
1,941
Death Reports
30
Reported Reactions
Death Report Ratio: High (11.38%)

Patient Demographics

Male
7,557
Female
7,015

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Mercaptopurine.

# Reaction Reports % of Total
1 FEBRILE NEUTROPENIA 1,877
11.1%
2 PYREXIA 1,183
7.0%
3 OFF LABEL USE 1,119
6.6%
4 DRUG INEFFECTIVE 1,095
6.4%
5 NAUSEA 783
4.6%
6 VOMITING 742
4.4%
7 DIARRHOEA 688
4.1%
8 ABDOMINAL PAIN 683
4.0%
9 HEADACHE 596
3.5%
10 NEUTROPENIA 592
3.5%
11 FATIGUE 549
3.2%
12 PNEUMONIA 515
3.0%
13 CROHN^S DISEASE 510
3.0%
14 SEPSIS 490
2.9%
15 ANAEMIA 467
2.8%
16 CONDITION AGGRAVATED 449
2.6%
17 PANCYTOPENIA 409
2.4%
18 BACTERIAL INFECTION 373
2.2%
19 ARTHRALGIA 371
2.2%
20 COUGH 365
2.1%
21 MYELOSUPPRESSION 345
2.0%
22 DYSPNOEA 332
2.0%
23 COLITIS ULCERATIVE 323
1.9%
24 THROMBOCYTOPENIA 321
1.9%
25 INJECTION SITE PAIN 309
1.8%
26 RASH 304
1.8%
27 VIRAL INFECTION 303
1.8%
28 MALAISE 298
1.8%
29 DEATH 295
1.7%
30 PAIN 293
1.7%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.