Valproate

Common brands: Keppra Xr, Keppra, Clozaril, Lamictal Odt, Lamictal Xr

Top reporter: Fresenius Kabi Usa, Llc

Atypical Antipsychotic [EPC]Benzodiazepine [EPC]Anti-epileptic Agent [EPC]Mood Stabilizer [EPC]Nonsteroidal Anti-inflammatory Drug [EPC]
20,101
Total Reports
11,208
Serious Reports
1,806
Death Reports
30
Reported Reactions
Death Report Ratio: High (8.98%)

Patient Demographics

Male
9,416
Female
8,400

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Valproate.

# Reaction Reports % of Total
1 DRUG INEFFECTIVE 1,428
7.5%
2 DRUG INTERACTION 1,230
6.5%
3 OFF LABEL USE 1,125
5.9%
4 FOETAL EXPOSURE DURING PREGNANCY 1,043
5.5%
5 SOMNOLENCE 976
5.1%
6 EPILEPSY 832
4.4%
7 SEIZURE 777
4.1%
8 TOXICITY TO VARIOUS AGENTS 770
4.1%
9 PYREXIA 749
3.9%
10 VOMITING 617
3.3%
11 CONVULSION 611
3.2%
12 NEUTROPENIA 536
2.8%
13 DIARRHOEA 524
2.8%
14 CONDITION AGGRAVATED 517
2.7%
15 WEIGHT INCREASED 509
2.7%
16 NAUSEA 508
2.7%
17 FATIGUE 496
2.6%
18 ANXIETY 476
2.5%
19 OVERDOSE 474
2.5%
20 CONFUSIONAL STATE 460
2.4%
21 SUICIDE ATTEMPT 456
2.4%
22 THROMBOCYTOPENIA 453
2.4%
23 TREMOR 447
2.4%
24 PRODUCT USE IN UNAPPROVED INDICATION 439
2.3%
25 PLATELET COUNT DECREASED 437
2.3%
26 FALL 436
2.3%
27 MALAISE 436
2.3%
28 AGGRESSION 414
2.2%
29 PNEUMONIA 406
2.1%
30 RASH 395
2.1%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.