Drugs with the Most Death Reports

These drugs have the most adverse event reports where the outcome included death. This does NOT mean these drugs caused the most deaths. FAERS reports are voluntary, unverified, and often involve patients with multiple medications and serious underlying conditions.

# Drug Name ↕ Generic Name ↕ Death Reports ↕ Total Reports ↕ Serious ↕
1 PAIN RELIEF ACETAMINOPHEN 62,730 448,952 217,329
2 LASIX FUROSEMIDE 60,616 387,999 138,474
3 GOODNOW PAIN RELIEF ACETAMINOPHEN 58,126 406,155 200,098
4 TYLENOL EXTRA STRENGTH ACETAMINOPHEN 57,894 399,311 210,285
5 TYLENOL REGULAR STRENGTH ACETAMINOPHEN 57,180 383,023 204,564
6 RAPIDOL ACETAMINOPHEN 52,969 291,586 170,021
7 REVLIMID LENALIDOMIDE 52,907 409,021 159,410
8 MEDLINE ACETAMINOPHEN 52,727 298,818 170,125
9 PREDNISONE TABLETS, USP, 10 MG PREDNISONE 50,086 482,841 203,210
10 PREDNISONE TABLETS, USP, 20 MG PREDNISONE 50,086 482,841 203,210
11 PREDNISONE TABLETS, USP, 5 MG PREDNISONE 50,086 482,841 203,210
12 PREDNISONE PREDNISONE 50,086 482,828 203,208
13 PREDNISONE DELAYED RELEASE PREDNISONE 50,086 482,828 203,208
14 ARTHRITIS PAIN RELIEVER ACETAMINOPHEN 49,581 264,730 158,536
15 TYLENOL EXTRA STRENGTH CAPLET ACETAMINOPHEN 47,670 257,774 153,404
16 PANADOL EXTRA STRENGTH ACETAMINOPHEN 47,307 242,194 148,232
17 PANADOL ACETAMINOPHEN 47,307 242,189 148,231
18 APAP ACETAMINOPHEN 47,159 241,537 147,729
19 TYLENOL 8HR ACETAMINOPHEN 46,985 241,606 148,181
20 PAIN RELIEVER ACETAMINOPHEN 46,975 240,087 147,234
21 FEVERALL INFANTS ACETAMINOPHEN 46,960 239,890 147,214
22 FEVERALL CHILDRENS ACETAMINOPHEN 46,960 239,867 147,215
23 FEVERALL JR. STRENGTH ACETAMINOPHEN 46,960 239,855 147,214
24 FEVERALL ACETAMINOPHEN 46,960 239,852 147,214
25 MAPAP EXTRA STRENGTH ACETAMINOPHEN 46,943 239,692 147,231
26 CHILDRENS TYLENOL ACETAMINOPHEN 46,934 241,146 147,417
27 TYLENOL 8 HR ARTHRITIS PAIN ACETAMINOPHEN 46,926 244,541 149,219
28 ACETAMINOPHEN ACETAMINOPHEN 46,921 239,594 147,239
29 PAIN RELIEF EXTRA STRENGTH ACETAMINOPHEN 46,920 239,609 147,236
30 ACETAMINOPHEN EXTRA STRENGTH ACETAMINOPHEN 46,919 239,484 147,155
31 PHARBETOL ACETAMINOPHEN 46,918 239,588 147,234
32 8HR ARTHRITIS PAIN RELIEF ACETAMINOPHEN 46,916 239,497 147,222
33 ACETAMINOPHEN 325MG ACETAMINOPHEN 46,916 239,495 147,221
34 PAIN RELIEVER EXTRA STRENGTH ACETAMINOPHEN 46,914 239,503 147,177
35 EXTRA STRENGTH PAIN RELIEVER ACETAMINOPHEN 46,911 239,497 147,172
36 INFANTS TYLENOL ACETAMINOPHEN 46,907 240,160 147,183
37 PAIN RELIEVER CHILDRENS ACETAMINOPHEN 46,900 239,415 147,147
38 ARTHRITIS PAIN ACETAMINOPHEN 46,900 239,376 147,151
39 DOLEX CHILDREN PAIN AND FEVER ACETAMINOPHEN 46,899 239,386 147,148
40 NON-ASPIRIN CHILDRENS ACETAMINOPHEN 46,899 239,352 147,139
41 EQUATE PAIN RELIEVER ACETAMINOPHEN 46,898 239,347 147,142
42 ACETAMINOPHEN 325 MG ACETAMINOPHEN 46,897 239,405 147,142
43 ACETAMINOPHEN 500 MG ACETAMINOPHEN 46,897 239,405 147,142
44 PAIN RELIEF CHILDRENS ACETAMINOPHEN 46,897 239,340 147,132
45 PAIN RELIEF CHILDRENS DYE FREE ACETAMINOPHEN 46,897 239,339 147,131
46 PAIN RELIEF EXTRA STRENGTH, NON-ASPIRIN ACETAMINOPHEN 46,897 239,339 147,131
47 PAIN RELIEF REGULAR STRENGTH ACETAMINOPHEN 46,897 239,339 147,131
48 MAX RELIEF JUNIOR ACETAMINOPHEN 46,897 239,334 147,131
49 CHILDRENS ACETAMINOPHEN ACETAMINOPHEN 46,897 239,333 147,131
50 CHILDRENS ACETAMINOPHEN DYE FREE GRAPE ACETAMINOPHEN 46,897 239,333 147,131

Key Takeaways

  • Death reports do not establish that the drug caused the death. Patients are often on multiple medications with serious underlying conditions.
  • Drugs used in oncology and critical care settings will naturally have higher death report counts.
  • The death-to-total-report ratio provides more context than raw death counts alone.

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. These rankings reflect reporting volume, not drug safety. Always consult your doctor or pharmacist before making medication decisions.