Bosentan

Common brands: Tracleer, Sildenafil, Sildenafil Citrate, Revatio, Adcirca

Top reporter: Actelion Pharmaceuticals Us, Inc.

Phosphodiesterase 5 Inhibitor [EPC]Prostacycline Vasodilator [EPC]Loop Diuretic [EPC]Nonsteroidal Anti-inflammatory Drug [EPC]Aldosterone Antagonist [EPC]
49,808
Total Reports
21,623
Serious Reports
15,916
Death Reports
30
Reported Reactions
Death Report Ratio: High (31.95%)

Patient Demographics

Male
10,152
Female
28,022

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Bosentan.

# Reaction Reports % of Total
1 DEATH 9,298
15.8%
2 DYSPNOEA 5,991
10.2%
3 PNEUMONIA 2,691
4.6%
4 PULMONARY ARTERIAL HYPERTENSION 2,290
3.9%
5 FATIGUE 2,246
3.8%
6 HEADACHE 2,221
3.8%
7 NAUSEA 2,063
3.5%
8 DIARRHOEA 1,988
3.4%
9 CONDITION AGGRAVATED 1,869
3.2%
10 DIZZINESS 1,761
3.0%
11 MALAISE 1,701
2.9%
12 FALL 1,568
2.7%
13 COUGH 1,550
2.6%
14 VOMITING 1,529
2.6%
15 PULMONARY HYPERTENSION 1,464
2.5%
16 FLUID RETENTION 1,434
2.4%
17 OEDEMA PERIPHERAL 1,395
2.4%
18 ASPARTATE AMINOTRANSFERASE INCREASED 1,385
2.4%
19 ALANINE AMINOTRANSFERASE INCREASED 1,372
2.3%
20 PYREXIA 1,269
2.2%
21 HYPOTENSION 1,264
2.2%
22 CHEST PAIN 1,259
2.1%
23 OFF LABEL USE 1,232
2.1%
24 ASTHENIA 1,209
2.1%
25 SYNCOPE 1,185
2.0%
26 CARDIAC FAILURE 1,170
2.0%
27 RIGHT VENTRICULAR FAILURE 1,136
1.9%
28 ANAEMIA 1,114
1.9%
29 HOSPITALISATION 1,026
1.7%
30 DISEASE PROGRESSION 1,025
1.7%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.