Leucovorin

Common brands: Vykoura, Efudex, Tolak, Fluorouracil, Oxaliplatin

Top reporter: Avyxa Pharma, Llc

Nucleoside Metabolic Inhibitor [EPC]Platinum-based Drug [EPC]Vascular Endothelial Growth Factor Inhibitor [EPC]Corticosteroid [EPC]Folate Analog Metabolic Inhibitor [EPC]
18,512
Total Reports
9,758
Serious Reports
2,480
Death Reports
30
Reported Reactions
Death Report Ratio: High (13.40%)

Patient Demographics

Male
8,850
Female
7,334

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Leucovorin.

# Reaction Reports % of Total
1 DIARRHOEA 1,748
8.7%
2 NAUSEA 1,342
6.7%
3 VOMITING 1,101
5.5%
4 NEUTROPENIA 1,067
5.3%
5 PYREXIA 981
4.9%
6 OFF LABEL USE 911
4.6%
7 FATIGUE 858
4.3%
8 DISEASE PROGRESSION 750
3.8%
9 DRUG INEFFECTIVE 701
3.5%
10 DYSPNOEA 698
3.5%
11 ASTHENIA 658
3.3%
12 ABDOMINAL PAIN 645
3.2%
13 FEBRILE NEUTROPENIA 629
3.1%
14 THROMBOCYTOPENIA 610
3.1%
15 DEHYDRATION 577
2.9%
16 ANAEMIA 564
2.8%
17 NEUROPATHY PERIPHERAL 562
2.8%
18 SEPSIS 502
2.5%
19 PAIN 488
2.4%
20 ARTHRALGIA 458
2.3%
21 RASH 451
2.3%
22 PNEUMONIA 445
2.2%
23 PULMONARY EMBOLISM 444
2.2%
24 HYPERTENSION 432
2.2%
25 HEADACHE 428
2.1%
26 HYPOTENSION 422
2.1%
27 DECREASED APPETITE 387
1.9%
28 MYELOSUPPRESSION 382
1.9%
29 MUCOSAL INFLAMMATION 372
1.9%
30 CONDITION AGGRAVATED 371
1.9%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.