Riociguat

Common brands: Adempas, Opsumit, Letairis, Remodulin, Ambrisentan

Top reporter: Bayer Healthcare Pharmaceuticals Inc.

Soluble Guanylate Cyclase Stimulator [EPC]Endothelin Receptor Antagonist [EPC]Prostacycline Vasodilator [EPC]Loop Diuretic [EPC]Prostacyclin Receptor Agonist [EPC]
31,875
Total Reports
16,559
Serious Reports
7,038
Death Reports
30
Reported Reactions
Death Report Ratio: High (22.08%)

Patient Demographics

Male
8,457
Female
22,637

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Riociguat.

# Reaction Reports % of Total
1 DYSPNOEA 5,642
8.8%
2 DEATH 5,366
8.4%
3 HEADACHE 4,448
6.9%
4 NAUSEA 3,720
5.8%
5 DIARRHOEA 3,489
5.4%
6 DIZZINESS 3,470
5.4%
7 HYPOTENSION 3,352
5.2%
8 FATIGUE 2,917
4.6%
9 HOSPITALISATION 2,297
3.6%
10 VOMITING 2,088
3.3%
11 OEDEMA PERIPHERAL 1,770
2.8%
12 COUGH 1,760
2.7%
13 PNEUMONIA 1,749
2.7%
14 FLUID RETENTION 1,743
2.7%
15 MALAISE 1,654
2.6%
16 PERIPHERAL SWELLING 1,625
2.5%
17 DYSPNOEA EXERTIONAL 1,532
2.4%
18 ASTHENIA 1,365
2.1%
19 CHEST PAIN 1,334
2.1%
20 PAIN IN EXTREMITY 1,299
2.0%
21 PAIN 1,265
2.0%
22 OXYGEN SATURATION DECREASED 1,233
1.9%
23 DYSPEPSIA 1,225
1.9%
24 FALL 1,183
1.8%
25 WEIGHT DECREASED 1,167
1.8%
26 DECREASED APPETITE 1,156
1.8%
27 PULMONARY ARTERIAL HYPERTENSION 1,115
1.7%
28 PAIN IN JAW 1,066
1.7%
29 OEDEMA 1,054
1.6%
30 SYNCOPE 1,018
1.6%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.