Divalproex

Common brands: Depakote Er, Depakote Sprinkles, Depakote, Seroquel Xr, Seroquel

Top reporter: Abbvie Inc.

Atypical Antipsychotic [EPC]Benzodiazepine [EPC]Anti-epileptic Agent [EPC]Nonsteroidal Anti-inflammatory Drug [EPC]Mood Stabilizer [EPC]
45,770
Total Reports
11,195
Serious Reports
2,541
Death Reports
30
Reported Reactions
Death Report Ratio: High (5.55%)

Patient Demographics

Male
19,837
Female
21,430

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Divalproex.

# Reaction Reports % of Total
1 DRUG INEFFECTIVE 3,012
6.5%
2 SEIZURE 2,558
5.5%
3 WEIGHT INCREASED 2,150
4.6%
4 NAUSEA 2,078
4.5%
5 OFF LABEL USE 2,025
4.4%
6 FATIGUE 1,929
4.2%
7 PAIN 1,890
4.1%
8 SOMNOLENCE 1,869
4.0%
9 TREMOR 1,810
3.9%
10 FALL 1,751
3.8%
11 ANXIETY 1,703
3.7%
12 VOMITING 1,615
3.5%
13 HEADACHE 1,575
3.4%
14 CONVULSION 1,562
3.4%
15 DEPRESSION 1,545
3.3%
16 INSOMNIA 1,539
3.3%
17 DIZZINESS 1,523
3.3%
18 DIARRHOEA 1,424
3.1%
19 DRUG INTERACTION 1,352
2.9%
20 DIABETES MELLITUS 1,307
2.8%
21 PNEUMONIA 1,096
2.4%
22 CONFUSIONAL STATE 1,092
2.4%
23 WEIGHT DECREASED 1,063
2.3%
24 ASTHENIA 1,038
2.2%
25 DYSPNOEA 1,037
2.2%
26 CONDITION AGGRAVATED 1,015
2.2%
27 FEELING ABNORMAL 995
2.1%
28 SUICIDAL IDEATION 971
2.1%
29 AGGRESSION 963
2.1%
30 MALAISE 956
2.1%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.