Dornase Alfa

Common brands: Pulmozyme, Creon, Tobi, Albuterol, 0.9%Saline

Top reporter: Genentech, Inc.

Recombinant Human Deoxyribonuclease 1 [EPC]Aminoglycoside Antibacterial [EPC]Cystic Fibrosis Transmembrane Conductance Regulator Potentiator [EPC]Osmotic Laxative [EPC]Proton Pump Inhibitor [EPC]
19,358
Total Reports
5,092
Serious Reports
811
Death Reports
30
Reported Reactions
Death Report Ratio: Moderate (4.19%)

Patient Demographics

Male
8,208
Female
9,973

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Dornase Alfa.

# Reaction Reports % of Total
1 INFECTIVE PULMONARY EXACERBATION OF CYSTIC FIBROSIS 2,295
11.7%
2 CYSTIC FIBROSIS 1,750
8.9%
3 HOSPITALISATION 1,301
6.6%
4 PNEUMONIA 1,281
6.5%
5 COUGH 989
5.0%
6 OFF LABEL USE 953
4.8%
7 INFECTION 941
4.8%
8 NO ADVERSE EVENT 929
4.7%
9 DYSPNOEA 905
4.6%
10 CONDITION AGGRAVATED 610
3.1%
11 HEADACHE 538
2.7%
12 PULMONARY FUNCTION TEST DECREASED 490
2.5%
13 DEATH 479
2.4%
14 MALAISE 467
2.4%
15 HAEMOPTYSIS 455
2.3%
16 PYREXIA 454
2.3%
17 FATIGUE 451
2.3%
18 INFLUENZA 447
2.3%
19 NASOPHARYNGITIS 380
1.9%
20 PRODUCTIVE COUGH 376
1.9%
21 NAUSEA 359
1.8%
22 DIARRHOEA 349
1.8%
23 LUNG DISORDER 325
1.7%
24 PSEUDOMONAS INFECTION 325
1.7%
25 WEIGHT DECREASED 321
1.6%
26 CYSTIC FIBROSIS RESPIRATORY INFECTION SUPPRESSION 309
1.6%
27 ABDOMINAL PAIN UPPER 304
1.5%
28 CHEST DISCOMFORT 299
1.5%
29 VOMITING 298
1.5%
30 ANXIETY 289
1.5%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.