Estradiol Transdermal

Common brands: Estradiol, Vagifem, Climara, Divigel, Dotti

Top reporter: Amneal Pharmaceuticals Ny Llc

Estrogen [EPC]Nonsteroidal Anti-inflammatory Drug [EPC]Benzodiazepine [EPC]Corticosteroid [EPC]Provitamin D2 Compound [EPC]
43,081
Total Reports
17,910
Serious Reports
864
Death Reports
30
Reported Reactions
Death Report Ratio: Moderate (2.01%)

Patient Demographics

Male
744
Female
39,284

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Estradiol Transdermal.

# Reaction Reports % of Total
1 DRUG INEFFECTIVE 3,532
7.9%
2 NAUSEA 2,669
6.0%
3 FATIGUE 2,652
5.9%
4 HEADACHE 2,623
5.9%
5 OFF LABEL USE 2,236
5.0%
6 PAIN 1,925
4.3%
7 DIARRHOEA 1,813
4.1%
8 BREAST CANCER FEMALE 1,709
3.8%
9 DIZZINESS 1,585
3.6%
10 ARTHRALGIA 1,509
3.4%
11 PRODUCT ADHESION ISSUE 1,452
3.3%
12 DYSPNOEA 1,411
3.2%
13 RASH 1,399
3.1%
14 PRURITUS 1,382
3.1%
15 VOMITING 1,267
2.8%
16 INSOMNIA 1,254
2.8%
17 MALAISE 1,176
2.6%
18 ANXIETY 1,175
2.6%
19 HOT FLUSH 1,134
2.5%
20 DEVICE ADHESION ISSUE 1,086
2.4%
21 PRODUCT DOSE OMISSION ISSUE 1,073
2.4%
22 FEELING ABNORMAL 1,062
2.4%
23 DEPRESSION 1,045
2.3%
24 PAIN IN EXTREMITY 1,015
2.3%
25 ASTHENIA 982
2.2%
26 WEIGHT INCREASED 947
2.1%
27 FALL 941
2.1%
28 CONDITION AGGRAVATED 851
1.9%
29 BACK PAIN 845
1.9%
30 COUGH 827
1.9%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.