Lapatinib

Common brands: Tykerb, Xeloda, Herceptin, Capecitabine 150mg, Capecitabine 500mg

Top reporter: Novartis Pharmaceuticals Corporation

Nucleoside Metabolic Inhibitor [EPC]HER2/neu Receptor Antagonist [EPC]Microtubule Inhibitor [EPC]Aromatase Inhibitor [EPC]Platinum-based Drug [EPC]
15,403
Total Reports
3,382
Serious Reports
2,460
Death Reports
30
Reported Reactions
Death Report Ratio: High (15.97%)

Patient Demographics

Male
673
Female
13,678

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Lapatinib.

# Reaction Reports % of Total
1 DIARRHOEA 4,171
18.9%
2 NAUSEA 1,613
7.3%
3 DEATH 1,453
6.6%
4 FATIGUE 1,304
5.9%
5 VOMITING 1,207
5.5%
6 RASH 1,060
4.8%
7 DISEASE PROGRESSION 999
4.5%
8 PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME 921
4.2%
9 ASTHENIA 604
2.7%
10 DRUG INEFFECTIVE 561
2.5%
11 DYSPNOEA 560
2.5%
12 MALIGNANT NEOPLASM PROGRESSION 559
2.5%
13 PYREXIA 527
2.4%
14 DEHYDRATION 524
2.4%
15 DECREASED APPETITE 519
2.4%
16 METASTASES TO CENTRAL NERVOUS SYSTEM 478
2.2%
17 NEUTROPENIA 470
2.1%
18 DRY SKIN 397
1.8%
19 STOMATITIS 373
1.7%
20 WEIGHT DECREASED 369
1.7%
21 PRURITUS 368
1.7%
22 DIZZINESS 366
1.7%
23 BREAST CANCER METASTATIC 360
1.6%
24 MALAISE 339
1.5%
25 ERYTHEMA 335
1.5%
26 HEADACHE 330
1.5%
27 ABDOMINAL PAIN 328
1.5%
28 PAIN IN EXTREMITY 324
1.5%
29 PAIN 321
1.5%
30 BREAST CANCER 300
1.4%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.