Linagliptin

Common brands: Tradjenta, Metformin Hydrochloride, Metformin, Lasix, Aspirin 325

Top reporter: Boehringer Ingelheim Pharmaceuticals, Inc.

Dipeptidyl Peptidase 4 Inhibitor [EPC]Nonsteroidal Anti-inflammatory Drug [EPC]Insulin Analog [EPC]Proton Pump Inhibitor [EPC]Loop Diuretic [EPC]
17,704
Total Reports
7,255
Serious Reports
1,652
Death Reports
30
Reported Reactions
Death Report Ratio: High (9.33%)

Patient Demographics

Male
7,932
Female
8,197

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Linagliptin.

# Reaction Reports % of Total
1 BLOOD GLUCOSE INCREASED 1,335
6.0%
2 DIARRHOEA 1,236
5.6%
3 NAUSEA 1,175
5.3%
4 FATIGUE 1,035
4.7%
5 DYSPNOEA 1,007
4.5%
6 OFF LABEL USE 953
4.3%
7 DIZZINESS 938
4.2%
8 VOMITING 906
4.1%
9 MALAISE 795
3.6%
10 ACUTE KIDNEY INJURY 778
3.5%
11 HEADACHE 760
3.4%
12 ARTHRALGIA 735
3.3%
13 PRURITUS 730
3.3%
14 PYREXIA 701
3.2%
15 DRUG INEFFECTIVE 656
3.0%
16 PAIN 647
2.9%
17 DEHYDRATION 614
2.8%
18 ABDOMINAL PAIN UPPER 606
2.7%
19 BACK PAIN 605
2.7%
20 CHEST PAIN 579
2.6%
21 PERIPHERAL SWELLING 566
2.5%
22 ABDOMINAL DISCOMFORT 564
2.5%
23 FALL 561
2.5%
24 COVID-19 559
2.5%
25 DEATH 556
2.5%
26 INSOMNIA 536
2.4%
27 MYOCARDIAL INFARCTION 536
2.4%
28 ANXIETY 529
2.4%
29 RASH 522
2.3%
30 FEELING ABNORMAL 502
2.3%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.