Pioglitazone

Common brands: Actos, Metformin Hydrochloride, Metformin, Ecotrin, Aspirin 325

Top reporter: Takeda Pharmaceuticals America, Inc.

Peroxisome Proliferator Receptor alpha Agonist [EPC]Peroxisome Proliferator Receptor gamma Agonist [EPC]Thiazolidinedione [EPC]Sulfonylurea [EPC]Nonsteroidal Anti-inflammatory Drug [EPC]
42,706
Total Reports
8,255
Serious Reports
4,305
Death Reports
30
Reported Reactions
Death Report Ratio: High (10.08%)

Patient Demographics

Male
18,421
Female
15,955

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Pioglitazone.

# Reaction Reports % of Total
1 BLADDER CANCER 8,738
19.3%
2 BLOOD GLUCOSE INCREASED 3,392
7.5%
3 NAUSEA 2,945
6.5%
4 WEIGHT DECREASED 2,087
4.6%
5 DIARRHOEA 1,713
3.8%
6 DEATH 1,547
3.4%
7 FATIGUE 1,493
3.3%
8 DRUG INEFFECTIVE 1,479
3.3%
9 VOMITING 1,452
3.2%
10 DYSPNOEA 1,413
3.1%
11 DIZZINESS 1,409
3.1%
12 DECREASED APPETITE 1,404
3.1%
13 WEIGHT INCREASED 1,296
2.9%
14 BLOOD GLUCOSE DECREASED 1,204
2.7%
15 ASTHENIA 1,162
2.6%
16 HEADACHE 1,096
2.4%
17 FALL 1,015
2.2%
18 OEDEMA PERIPHERAL 1,006
2.2%
19 PAIN 952
2.1%
20 RENAL FAILURE 938
2.1%
21 CARDIAC FAILURE CONGESTIVE 887
2.0%
22 MYOCARDIAL INFARCTION 846
1.9%
23 HYPOGLYCAEMIA 797
1.8%
24 MALAISE 767
1.7%
25 CHRONIC KIDNEY DISEASE 761
1.7%
26 ACUTE KIDNEY INJURY 723
1.6%
27 ARTHRALGIA 723
1.6%
28 OFF LABEL USE 687
1.5%
29 PAIN IN EXTREMITY 685
1.5%
30 PNEUMONIA 670
1.5%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.