Drugs with the Highest Death Report Ratio

This ranking shows drugs with the highest percentage of reports involving a death outcome. This does NOT mean these drugs are the most dangerous. FAERS reports are voluntary, unverified, and do not establish that the drug caused the death. Many factors contribute to outcomes.

# Drug Name ↕ Generic Name ↕ Death Ratio ↕ Death Reports ↕ Total Reports ↕
1 GENEXA INFANTS PAIN AND FEVER ACETAMINOPHEN 19.6% 46,896 239,317
2 MEJORALITO ACETAMINOPHEN 19.6% 46,896 239,317
3 RUGBY REGULAR STRENGTH ACETAMINOPHEN ACETAMINOPHEN 19.6% 46,896 239,317
4 REGULAR STRENGTH ACETAMINOPHEN ACETAMINOPHEN 19.6% 46,896 239,318
5 ACETAMINOPHEN EXTENDED-RELEASE ACETAMINOPHEN 19.6% 46,896 239,321
6 365 WHOLE FOODS MARKET ACETAMINOPHEN ACETAMINOPHEN 19.6% 46,895 239,316
7 8 HOUR ARTHRITIS PAIN ACETAMINOPHEN 19.6% 46,895 239,316
8 8 HOUR PAIN RELIEF ACETAMINOPHEN 19.6% 46,895 239,316
9 8 HR ARTHRITIS PAIN ACETAMINOPHEN 19.6% 46,895 239,316
10 8 HR ARTHRITIS PAIN RELIEF ACETAMINOPHEN 19.6% 46,895 239,316
11 8 HR MUSCLE ACHES AND PAIN ACETAMINOPHEN 19.6% 46,895 239,316
12 8 HR PAIN RELIEF ACETAMINOPHEN 19.6% 46,895 239,316
13 8HR ARTHRITIS PAIN ACETAMINOPHEN 19.6% 46,895 239,316
14 8HR MUSCLE ACHES AND PAIN ACETAMINOPHEN 19.6% 46,895 239,316
15 8HR MUSCLE ACHES AND PAIN RELIEF ACETAMINOPHEN 19.6% 46,895 239,316
16 8HR PAIN RELIEF ACETAMINOPHEN 19.6% 46,895 239,316
17 ACETAMINOPHEN (RED) ACETAMINOPHEN 19.6% 46,895 239,316
18 ACETAMINOPHEN - APAP 8 HOUR ACETAMINOPHEN 19.6% 46,895 239,316
19 ACETAMINOPHEN - APAP ARTHRITIS ACETAMINOPHEN 19.6% 46,895 239,316
20 ACETAMINOPHEN CAPLETS ACETAMINOPHEN 19.6% 46,895 239,316
21 ACETAMINOPHEN EASY TABS EXTRA STRENGTH ACETAMINOPHEN 19.6% 46,895 239,316
22 ACETAMINOPHEN EXTENDED-RELEASE TABLETS, 650 MG ACETAMINOPHEN 19.6% 46,895 239,316
23 ACETAMINOPHEN GELCAPS ACETAMINOPHEN 19.6% 46,895 239,316
24 ACETAMINOPHEN GELCAPS EXTRA STRENGTH ACETAMINOPHEN 19.6% 46,895 239,316
25 ACETAMINOPHEN SOLUTION ACETAMINOPHEN 19.6% 46,895 239,316
26 ADWE CHILDRENS PAIN FEVER ACETAMINOPHEN 19.6% 46,895 239,316
27 ADWE FEVERX ACETAMINOPHEN CAPLETS, 500 MG EXTRA STRENGTH ACETAMINOPHEN 19.6% 46,895 239,316
28 AMAZON BASIC CARE ACETAMINOPHEN ACETAMINOPHEN 19.6% 46,895 239,316
29 APHEN ACETAMINOPHEN 19.6% 46,895 239,316
30 ARTHRITISPAIN RELIEF ACETAMINOPHEN 19.6% 46,895 239,316
31 AUROPHEN EXTRA STRENGTH FOR ADULTS ACETAMINOPHEN 19.6% 46,895 239,316
32 AUROPHEN REGULAR STRENGTH ACETAMINOPHEN 19.6% 46,895 239,316
33 BACTIMICINA CHILDRENS PAIN AND FEVER ACETAMINOPHEN 19.6% 46,895 239,316
34 BASIC CARE ACETAMINOPHEN ACETAMINOPHEN 19.6% 46,895 239,316
35 BASIC CARE CHILDRENS PAIN AND FEVER ACETAMINOPHEN 19.6% 46,895 239,316
36 BASIC CARE INFANTS PAIN AND FEVER ACETAMINOPHEN 19.6% 46,895 239,316
37 BERKLEY AND JENSEN ACETAMINOPHEN ACETAMINOPHEN 19.6% 46,895 239,316
38 BERKLEY AND JENSEN PAIN RELIEF ACETAMINOPHEN 19.6% 46,895 239,316
39 BERKLEY AND JENSEN RAPID RELEASE ACETAMINOPHEN ACETAMINOPHEN 19.6% 46,895 239,316
40 BETTER LIVING BRANDS CHILDRENS FEVER AND PAIN RELIVER ACETAMINOPHEN 19.6% 46,895 239,316
41 CABINET PAIN RELIEVER AND FEVER REDUCER REFILL ACETAMINOPHEN ACETAMINOPHEN 19.6% 46,895 239,316
42 CARE ONE ARTHRITIS PAIN RELIEF ACETAMINOPHEN 19.6% 46,895 239,316
43 CAREALL ACETAMINOPHEN ACETAMINOPHEN 19.6% 46,895 239,316
44 CAREALL ACETAMINOPHEN EXTRA STRENGTH ACETAMINOPHEN 19.6% 46,895 239,316
45 CAREALL NON ASPIRIN EXTRA STRENGTH ACETAMINOPHEN 19.6% 46,895 239,316
46 CAREONE 8 HOUR PAIN RELIEF ACETAMINOPHEN 19.6% 46,895 239,316
47 CAREONE CHILDRENS ACETAMINOPHEN ACETAMINOPHEN 19.6% 46,895 239,316
48 CAREONE INFANTS ACETAMINOPHEN ACETAMINOPHEN 19.6% 46,895 239,316
49 CETAFEN EXTRA ACETAMINOPHEN 19.6% 46,895 239,316
50 CHEWABLE ACETAMINOPHEN CHILDRENS ACETAMINOPHEN 19.6% 46,895 239,316

Key Takeaways

  • A high death ratio often reflects the severity of the condition being treated, not the danger of the drug itself.
  • Chemotherapy and end-of-life care drugs will naturally have elevated death ratios.
  • Only drugs with at least 1,000 total reports are included to avoid statistical noise from small sample sizes.

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. These rankings reflect reporting volume, not drug safety. Always consult your doctor or pharmacist before making medication decisions.