Estradiol

Common brands: Estrace, Estradiol Transdermal System, Estring, Vagifem, Climara

Top reporter: Allergan, Inc.

Estrogen [EPC]Nonsteroidal Anti-inflammatory Drug [EPC]Benzodiazepine [EPC]Corticosteroid [EPC]Provitamin D2 Compound [EPC]
86,101
Total Reports
27,715
Serious Reports
1,510
Death Reports
30
Reported Reactions
Death Report Ratio: Moderate (1.75%)

Patient Demographics

Male
1,064
Female
78,813

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Estradiol.

# Reaction Reports % of Total
1 DRUG INEFFECTIVE 7,776
8.6%
2 OFF LABEL USE 5,667
6.3%
3 PRODUCT ADHESION ISSUE 5,599
6.2%
4 HEADACHE 5,139
5.7%
5 NAUSEA 4,864
5.4%
6 FATIGUE 4,614
5.1%
7 PAIN 3,544
3.9%
8 HOT FLUSH 3,340
3.7%
9 DIARRHOEA 3,137
3.5%
10 DIZZINESS 2,975
3.3%
11 ARTHRALGIA 2,874
3.2%
12 RASH 2,552
2.8%
13 PRURITUS 2,501
2.8%
14 PRODUCT QUALITY ISSUE 2,491
2.8%
15 DYSPNOEA 2,484
2.7%
16 INSOMNIA 2,469
2.7%
17 BREAST CANCER FEMALE 2,439
2.7%
18 MALAISE 2,374
2.6%
19 NO ADVERSE EVENT 2,353
2.6%
20 WRONG TECHNIQUE IN PRODUCT USAGE PROCESS 2,246
2.5%
21 ANXIETY 2,200
2.4%
22 VOMITING 2,134
2.4%
23 FEELING ABNORMAL 2,128
2.3%
24 PAIN IN EXTREMITY 1,966
2.2%
25 BREAST CANCER 1,880
2.1%
26 WEIGHT INCREASED 1,839
2.0%
27 DEPRESSION 1,838
2.0%
28 ASTHENIA 1,768
2.0%
29 BACK PAIN 1,689
1.9%
30 FALL 1,677
1.9%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.