Regorafenib

Common brands: Stivarga, Avastin, Nexavar, Lonsurf, Oxaliplatin

Top reporter: Bayer Healthcare Pharmaceuticals Inc.

Nucleoside Metabolic Inhibitor [EPC]Kinase Inhibitor [EPC]Vascular Endothelial Growth Factor Inhibitor [EPC]Nucleoside Analog Antiviral [EPC]Platinum-based Drug [EPC]
11,442
Total Reports
4,943
Serious Reports
2,347
Death Reports
30
Reported Reactions
Death Report Ratio: High (20.51%)

Patient Demographics

Male
6,294
Female
4,157

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Regorafenib.

# Reaction Reports % of Total
1 OFF LABEL USE 2,059
9.4%
2 FATIGUE 1,762
8.1%
3 PALMAR-PLANTAR ERYTHRODYSAESTHESIA SYNDROME 1,432
6.5%
4 DIARRHOEA 1,410
6.4%
5 DECREASED APPETITE 1,085
5.0%
6 DEATH 991
4.5%
7 ASTHENIA 941
4.3%
8 DYSPHONIA 820
3.7%
9 NAUSEA 809
3.7%
10 PAIN IN EXTREMITY 770
3.5%
11 PYREXIA 748
3.4%
12 HYPERTENSION 691
3.2%
13 WEIGHT DECREASED 633
2.9%
14 VOMITING 569
2.6%
15 RASH 553
2.5%
16 PAIN 535
2.4%
17 NEUROPATHY PERIPHERAL 502
2.3%
18 HEPATOCELLULAR CARCINOMA 487
2.2%
19 ABDOMINAL PAIN 477
2.2%
20 DYSPNOEA 466
2.1%
21 DEHYDRATION 456
2.1%
22 BLISTER 454
2.1%
23 BLOOD PRESSURE INCREASED 454
2.1%
24 DRUG INEFFECTIVE 432
2.0%
25 HEADACHE 430
2.0%
26 CONSTIPATION 422
1.9%
27 MALAISE 410
1.9%
28 ABDOMINAL PAIN UPPER 370
1.7%
29 SKIN EXFOLIATION 355
1.6%
30 GAIT DISTURBANCE 350
1.6%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.