Apremilast

Common brands: Otezla, Methotrexate, Rasuvo, Otrexup, Trexall

Top reporter: Amgen, Inc

Phosphodiesterase 4 Inhibitor [EPC]Nonsteroidal Anti-inflammatory Drug [EPC]Corticosteroid [EPC]Folate Analog Metabolic Inhibitor [EPC]Tumor Necrosis Factor Blocker [EPC]
144,030
Total Reports
29,889
Serious Reports
5,673
Death Reports
30
Reported Reactions
Death Report Ratio: Moderate (3.94%)

Patient Demographics

Male
46,535
Female
90,918

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Apremilast.

# Reaction Reports % of Total
1 DIARRHOEA 24,445
11.0%
2 NAUSEA 22,018
9.9%
3 PSORIASIS 20,366
9.2%
4 HEADACHE 17,784
8.0%
5 DRUG INEFFECTIVE 15,439
7.0%
6 ABDOMINAL DISCOMFORT 8,145
3.7%
7 PSORIATIC ARTHROPATHY 7,958
3.6%
8 PAIN 6,733
3.0%
9 RASH 6,607
3.0%
10 VOMITING 6,427
2.9%
11 ARTHRALGIA 6,317
2.9%
12 FATIGUE 6,112
2.8%
13 DEPRESSION 5,488
2.5%
14 OFF LABEL USE 5,148
2.3%
15 WEIGHT DECREASED 4,992
2.3%
16 ABDOMINAL PAIN UPPER 4,823
2.2%
17 PRODUCT DOSE OMISSION ISSUE 4,767
2.2%
18 PRODUCT DOSE OMISSION 4,594
2.1%
19 MALAISE 4,558
2.1%
20 PRURITUS 4,225
1.9%
21 DECREASED APPETITE 3,823
1.7%
22 CONDITION AGGRAVATED 3,774
1.7%
23 THERAPY NON-RESPONDER 3,726
1.7%
24 DIZZINESS 3,380
1.5%
25 INSOMNIA 3,322
1.5%
26 JOINT SWELLING 3,311
1.5%
27 ADVERSE DRUG REACTION 3,309
1.5%
28 NASOPHARYNGITIS 3,278
1.5%
29 ALOPECIA 3,248
1.5%
30 RHEUMATOID ARTHRITIS 3,239
1.5%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.