Methotrexate

Common brands: Rasuvo, Otrexup, Trexall, Xatmep, Jylamvo

Top reporter: Medexus Pharma Inc.

Folate Analog Metabolic Inhibitor [EPC]Tumor Necrosis Factor Blocker [EPC]Corticosteroid [EPC]Vitamin C [EPC]Vitamin B12 [EPC]
413,991
Total Reports
134,588
Serious Reports
33,134
Death Reports
30
Reported Reactions
Death Report Ratio: High (8.00%)

Patient Demographics

Male
108,348
Female
261,791

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for Methotrexate.

# Reaction Reports % of Total
1 DRUG INEFFECTIVE 75,458
11.7%
2 RHEUMATOID ARTHRITIS 38,303
6.0%
3 ARTHRALGIA 36,561
5.7%
4 PAIN 35,700
5.6%
5 OFF LABEL USE 34,124
5.3%
6 FATIGUE 29,326
4.6%
7 NAUSEA 24,213
3.8%
8 JOINT SWELLING 22,467
3.5%
9 HEADACHE 21,053
3.3%
10 RASH 19,996
3.1%
11 CONDITION AGGRAVATED 19,836
3.1%
12 DRUG INTOLERANCE 19,702
3.1%
13 DIARRHOEA 18,395
2.9%
14 PAIN IN EXTREMITY 18,024
2.8%
15 PYREXIA 17,138
2.7%
16 PNEUMONIA 16,325
2.5%
17 MALAISE 15,335
2.4%
18 VOMITING 15,187
2.4%
19 ALOPECIA 14,832
2.3%
20 TREATMENT FAILURE 14,606
2.3%
21 DYSPNOEA 14,531
2.3%
22 NASOPHARYNGITIS 14,273
2.2%
23 ABDOMINAL DISCOMFORT 14,195
2.2%
24 INJECTION SITE PAIN 14,084
2.2%
25 INFECTION 13,649
2.1%
26 PERIPHERAL SWELLING 13,376
2.1%
27 ARTHROPATHY 13,270
2.1%
28 MUSCULOSKELETAL STIFFNESS 13,061
2.0%
29 CONTRAINDICATED PRODUCT ADMINISTERED 13,055
2.0%
30 DRUG HYPERSENSITIVITY 12,481
1.9%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.