OTREXUP

Generic: METHOTREXATE

Manufacturer: Antares Pharma, Inc.

Folate Analog Metabolic Inhibitor [EPC]Tumor Necrosis Factor Blocker [EPC]Corticosteroid [EPC]Vitamin C [EPC]Vitamin B12 [EPC]
405,468
Total Reports
129,426
Serious Reports
32,432
Death Reports
30
Reported Reactions
Death Report Ratio: High (8.00%)

Patient Demographics

Male
106,413
Female
255,959

Reported Adverse Reactions (30)

Side effects reported in FDA adverse event reports for OTREXUP.

# Reaction Reports % of Total
1 DRUG INEFFECTIVE 74,549
11.8%
2 RHEUMATOID ARTHRITIS 37,769
6.0%
3 ARTHRALGIA 35,938
5.7%
4 PAIN 35,104
5.6%
5 OFF LABEL USE 33,339
5.3%
6 FATIGUE 28,830
4.6%
7 NAUSEA 23,766
3.8%
8 JOINT SWELLING 22,140
3.5%
9 HEADACHE 20,664
3.3%
10 RASH 19,680
3.1%
11 DRUG INTOLERANCE 19,510
3.1%
12 CONDITION AGGRAVATED 19,506
3.1%
13 DIARRHOEA 18,091
2.9%
14 PAIN IN EXTREMITY 17,717
2.8%
15 PYREXIA 16,861
2.7%
16 PNEUMONIA 16,037
2.5%
17 MALAISE 14,970
2.4%
18 VOMITING 14,919
2.4%
19 ALOPECIA 14,549
2.3%
20 TREATMENT FAILURE 14,423
2.3%
21 DYSPNOEA 14,298
2.3%
22 NASOPHARYNGITIS 14,000
2.2%
23 ABDOMINAL DISCOMFORT 13,993
2.2%
24 INJECTION SITE PAIN 13,771
2.2%
25 INFECTION 13,393
2.1%
26 PERIPHERAL SWELLING 13,164
2.1%
27 ARTHROPATHY 13,134
2.1%
28 CONTRAINDICATED PRODUCT ADMINISTERED 12,938
2.0%
29 MUSCULOSKELETAL STIFFNESS 12,858
2.0%
30 DRUG HYPERSENSITIVITY 12,361
2.0%

Important Disclaimer

FDA adverse event reports are submitted voluntarily and do not prove causation. A reported reaction does not mean the drug caused it. Drugs with more users naturally have more reports. Always consult your doctor or pharmacist before making medication decisions.